Mammalian cytokines; receptors; related reagents and methods

Details Mammalian cytokines; receptors; related reagents and methods Mammalian cytokines; receptors; related reagents and methods

2005-01-18

2005-01-18

Andres, Janet (Department: 1646)

Drug, bio-affecting and body treating compositions

Lymphokine

Interleukin

C424S085100, C424S158100, C514S002600, C530S351000, C530S388100, C530S389100, C435S069520

Reexamination Certificate

active

06843987

ABSTRACT:
Nucleic acids encoding mammalian, e.g., rodent, IL-1δ, IL-1ε, purified IL-1δ and IL-1ε proteins and fragments thereof. Antibodies, both polyclonal and monoclonal, are also provided. Methods of using the compositions for both diagnostic and therapeutic utilities are provided.

REFERENCES:
patent: 5863769 (1999-01-01), Young
patent: 6054559 (2000-04-01), Young
patent: 0 855 404 (1998-07-01), None
patent: WO 9935268 (1999-07-01), None
patent: WO 9936541 (1999-07-01), None
patent: WO 9937662 (1999-07-01), None
patent: WO 9607739 (2002-03-01), None
McColl and Lewis, J. Immunol. 1999, vol. 163(5), pp. 2829-2835.*
Jenny L. Barton, et al.,Eur. J. Immunol., 30:3299-3308, 2000. “A tissue specific IL-1 receptor antagonist homolog from the IL-1 cluster lacks IL-1 cluster lacks IL-1, IL-1ra, IL-18 and IL-18 antagonist activities”.
J. Fernando Bazan, et al.,Nature, 379:591, February 15, 1996. “A newly defined interleukin-1?”.
Teresa L. Born, et al.,J. Biological Chemistry, 273(45):29445-29450, Nov. 6, 1998. “Cloning of a Novel Receptor Subunit, AcPL, Required for Interleukin-18 Signaling”.
Alain Carrie, et al.,Nature Genet., 23:25-31, Sep. 1999. “A new member of the IL-1 receptor family highly expressed in hippocampus and involved in X-linked mental retardation”.
M. Dale and MJ Nicklen,Genomics, 57:177-179, 1999. “Interleukin-1 receptor cluster: gene organization of IL1R2, IL1R1, IL1RL2 (IL-1Rrp2), IL1RL1 (T1/ST2), and IL18R1 (IL-1Rrp) on human chromosome 2q”.
R. Debets, et al.,EMBL Database, Accession No. AF206696, Dec. 1, 2000. “Novel IL-1 family member IL-1e respondes through the orphan IL-1R related protein 2; response is antagonized by IL-1d”.
Charles A. Dinarello,Blood, 87(6):2095-2147, Mar. 15, 1996. “Biologic basis for interleukin-1 in disease”.
Tariq Ghayur, et al.,Nature, 386(6625):619-623, Apr. 10, 1997. “Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production”.
Yong Gu, et al,.Science, 275(5297):206-209, Jan. 10, 1997. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme.
Hirotada Kojima, et al.,Biochem, Biophys, Res. Commun., 244(1):183-186, Mar. 6, 1998. “Interleukin-18 activates the IRAK-TRAF6 pathway in mouse EL-4 cells”.
Sanjay Kumar, et al.,J. Biol. Chem., 275(14):10308-10314, Apr. 7, 2000. “Identification and Initial Characterization of Four Novel Members of the Interleukin-1 Family”.
Timothy W. Lovenberg, et al.,J. Neuroimmunol., 70:113-122, 1996. “Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL1R-rp2)”.
M. Marra, et al.,GenBank, Accession No. AA030324, Aug. 19, 1996. “The WashU-HHMI Mouse EST Project”.
M. Marra, et al.,GenBank, Accession No. WO8205, Apr. 25, 1996. “The WashU-HHMI Mouse EST Project”.
Julio J. Mulero, et al.,Biochem, Biophys. Res. Commun., 263(3):702-706, Oct. 1999. “IL1HY1: A Novel Interleukin-1 Receptor Antagonist Gene”.
Luke A.J. O'Neill and Catherine Greene,J. Leukoc. Biol., 63(6):650-657, Jun. 1998. “Signal transduction pathways activated by the IL-1 receptor family: ancient signaling machinery in mammals, insects, and plants”.
Patricia Parnet, et al.,J. Biological Chemistry, 271(8):3967-3970, Feb. 23, 1996. “IL-1Rrp Is a Novel Receptor-like Molecule Similar to the Type I Interleulin-1 Receptor and Its Homologues T1/ST/2 and IL-1R AcP”.
Douglas Robinson, et al.,Immunity, 7:571-581, Oct. 1997. “IGIF Does Not Drive Th1 development but Synergizes with IL-12 for Interferon-γ Production and Activates IRAK and NFκB”.
Fernando Rock, et al.,P.N.A.S. USA, 95:588-593, Jan. 1998. “A family of human receptors structurally related toDrosophiliaToll”.
Dirk E. Smith, et al.,J. Biol. Chem., 275(2):1169-1175, Jan. 14, 2000. “Four New Members Expand the Interleukin-1 Superfamily”.
Elisabeth Thomasson, et al.,Cytokine11(6):389-399, Jun. 1999. “Identification and Characterization of SIGIRR, A Molecule Representing a Novel Subtype of the IL-1r Superfamily”.
Kakuji Torigoe, et al.,J. Biol. Chem., 272(41):25737-25742, Oct. 10, 1997. “Purification and Characterization of the Human Interleukin-18 Receptor”.
Shimpei Ushio, et al.J. Immunol., 156:4274-4279, 1996. “Cloning of the cDNA for Human IFN-γ-Inducing Factor, Expression inEscherichia coli, and Studies on the Bilogical Activities of the Protein”.
Lawrence Weissbach, et al.,Biochem Biophys Res Commun, 244(1):91-95, Mar. 6, 1998. “Detection of an interleukin-1 intracellular receptor antagonist mRNA variant”.

Affiliated with

Also associated with

Rating

Mammalian cytokines; receptors; related reagents and methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Mammalian cytokines; receptors; related reagents and methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mammalian cytokines; receptors; related reagents and methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3419632