Mammalian cell death preventing kinase, DPK

Chemistry: molecular biology and microbiology – Enzyme – proenzyme; compositions thereof; process for... – Transferase other than ribonuclease

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435193, C12N 912

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active

059812486

ABSTRACT:
Disclosed are nucleic acids encoding novel proteins, designated DPK. Also disclosed are amino acid sequences for DPK polypeptides, methods for preparing DPK polypeptides, and other related aspects.

REFERENCES:
Hoang et al, "Participation of cyclin A in Myc-induced apoptosis," PNAS USA, vol. 91, No. 15, pp. 6875-6879 (1994).
Schultz et al. Identification of 21 novel human protein kinases, including 3 members of a family related to the cell cycle regulator nimA of Aspergillus nidulans. Cell Growth and Differentiation. 4: 821-830, Oct., 1993.
The Merck Index, eighth edition. NJ: Merck & Co, Inc. p. 497, 1968.
Broome, et al., "Apoptosis and Bcl-2 expression in cultured murine splenic T cells," Immunology, vol. 84, pp. 375-382, 1995.
Broome, et al., "Expression of Bcl-2, Bcl-x, and Bax after T Cell Activation and IL-2 Withdrawal," The Journal of Immunology, vol. 155:2311-2317, 1995.
Collins et al., "The cell cycle and cancer," Proc.Natl.Acad.Sci.USA, vol. 94, pp. 2776-2778, Apr. 1997.
Deng, et al., "Suppression of apoptosis in a cytotoxic T-cell line by interleukin 2-mediated gene transcription and deregulated expression of the protooncogene bcl-2," Proc.Natl.Acad.Sci.USA, vol. 90, pp. 2189-2193, Mar. 1993.
Edgar et al., "Distinct molecular mechanisms regulate cell cycle timing at successive stages of Drosophila embryogenesis," Genes & Development, vol. 8:440-452, 1994.
Elledge, "Cell Cycle Checkpoints: Preventing an Identity Crisis," Science, vol. 274, pp. 1664, Dec. 1996.
Fang et al., "Cloning and Molecular Characterization of Mouse bcl-x in B and T Lymphocytes," The Journal of Immunology, vol. 153:4388, 1994.
Gonzalez-Garcia et al., "bcl-x.sub.L is the major bcl-x mRNA form expressed during murine development and its product localizes to mitochondria," Development, vol. 120, pp. 3033-3042, 1994.
Hanks et al., "The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains," Science, vol. 241, pp. 42, 1988.
Hunter et al., "Cyclins and Cancer II: Cyclin D and CDK Inhibitors Come of Age," Cell, vol. 79, pp. 573-582, Nov. 1994.
Leclerc et al., "Drosophila Cdk8, a Kinase Partner of Cyclin C that Interacts with the Large Subunit of RNA Polymerase II," Molecular Biology of the Cell, vol. 7, pp. 505-513, Apr. 1996.
Matsushime et al., "Identification and Properties of an Atypical Catalytic Subunit (p34.sup.PSK-J3 /cdk4) for Mammalian D Type G1 Cyclins," Cell, vol. 71, pp. 323-334, Oct. 1992.
Morgan, "Principles of CDK regulation," Nature, vol. 374, pp. 131, Mar. 1995.
Nasmyth, "Viewpoint: Putting the Cell Cycle in Order," Science, vol. 274, pp. 1643, Dec. 1996.
Negrini et al., "Molecular Analysis of mbcl-2: Structure and Expression of the Murine Gene Homologous to the Human Gene Involved in Follicular Lymphoma," Cell, vol. 49, pp. 455-463, May 1987.
Nourse et al., "Interleukin-2-mediated elimination of the p27.sup.Kip1 cyclin-dependent kinase inhibitor prevented by rapamycin," Nature, vol. 372, pp. 570-573, Dec. 1994.
Nunez, et al., "Deregulated Bcl-2 Gene Expression Selectively Prolongs Survival of Growth Factor-Deprived Hemopoietic Cell Lines," The Journal of Immunology, vol. 144, pp. 3602-3610, May 1, 1990.
Oltvai et al., "Bcl-2 Heterodimerizes In Vivo with a Conserved Homolog, Bax, That Accelerates Programmed Cell Death," Cell, vol. 74, pp. 609-619, Aug. 1993.
Reed, "Double identity for proteins of the Bcl-2 family," Nature, vol. 387, pp. 773-776, Jun. 1997.
Reed, "Regulation of apoptosis by bcl-2 family proteins and its role in cancer and chemoresistance," Current Opinion in Oncology, vol. 7:541-546, 1995.
Rudin et al., "Apoptosis and Disease: Regulation and Clinical Relevance of Programmed Cell Death," Annu.Rev.Med. 48:267-81, 1997.
Salomini et al., "Resistance to apoptosis in CTLL-2 cells constitutively expressing c-Myb is associated with induction of BCL-2 expression and Myb-dependent regulation of bcl-2 promoter activity," Proc.Natl.Acad.Sci.USA, vol. 94, pp. 3296-3301, Apr. 1997.
Sherr, "Cancer Cell Cycles," Science, vol. 274, pp. 1672, Dec. 1996.
Siliciano et al., "itk, a T-cell-specific tyrosine kinase gene inducible by interleukin 2," Proc.Natl.Acad.Sci.USA, vol. 89, pp. 11194-11198, 1992.
Stillman, "Cell Cycle Control of DNA Replication," Science, vol. 274, pp. 1659, Dec. 1996.
Surosky et al., "The Yeast UME5 Gene Regulates the Stability of Meiotic mRNAs in Response to Glucose," Molecular and Cellular Biology, vol. 14, pp. 3446-3458, May 1994.
Tassan et al., Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C, Proc.Natl.Acad.Sci.USA, vol. 92, pp. 8871-8875, Sep. 1995.
Weller, et al., "Transforming growth factor-.beta..sub.2 induces apoptosis of murine T cell clones without down-regulating bcl-2 mRNA expression," Eur.J.Immunol., vol. 24:1293-1300, 1994.
Yang, et al., "Bad, a Heterodimeric Partner for Bcl-x.sub.L and Bcl-2, Displaces Bax and Promotes Cell Death," Cell, vol. 80, pp. 285-291, Jan. 1995.

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