Mammalian CDP-diacylglycerol synthase

Details Mammalian CDP-diacylglycerol synthase Mammalian CDP-diacylglycerol synthase

1996-06-28

1999-09-14

Patterson, Jr., Charles L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

435194, C12N 1554

Patent

active

059524804

ABSTRACT:
There is disclosed cDNA sequences and polypeptides having the enzyme CDP-diacylglycerol synthase (CDS) activity. CDS is also known as CTP:phosphatidate cytidylytransferase. There is further disclosed methods for isolation and production of polypeptides involved in phosphatidic acid metabolism and signaling in mammalian cells, in particular, the production of purified forms of CDS.

REFERENCES:
Hancock, A. M., et. al. (1996) J. Neurochem. 67(5), 2200-2203.
Saito, S., et. al. (1997) J. Biol. Chem. 272(14), 9503-9509.
Icho, T., et. al. (1985) J. Biol. Chem. 260(22), 12078-12083.

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