Mammalian augmenter of liver regeneration and variants thereof

Details Mammalian augmenter of liver regeneration and variants thereof Mammalian augmenter of liver regeneration and variants thereof

1995-01-03

1997-03-04

Jacobson, Dian C.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4352523, 43525233, 43525411, 4353201, 435354, 435360, 4353651, 536 232, C12N 121, C12N 1512, C12N 1563, C12P 2100

Patent

active

056078447

ABSTRACT:
Full-length cDNA clones have been isolated encoding purified augmenter of liver regeneration (ALR) polypeptides prepared from the cytosol of livers from weanling rats and from humans. The full-length clone from the rat is a 1226 bp cDNA containing an 81 bp 5'-untranslated region, a 594 bp coding region and a 551 bp 3'-untranslated region. The coding region encodes three proteins with estimated molecular weights of 15,081, 20,193 and 22,835. The full-length clone from the human consists of a 727 bp cDNA containing a 4 bp 5'-untranslated region, a 615 bp coding region and a 108 bp 3'-untranslated region, including the termination codon TAG and the poly (A) region. The 615 bp coding region encodes four proteins, human ALR-V1, ALR-V2, ALR-V3 and ALR, having estimated molecular weights of 23,448, 20,834, 20,703 and 15,028, respectively.

REFERENCES:
Francavilla et al., "Extraction and Partial Purification of a Hepatic Stimulatory Substance in Rats, Mice, and Dogs," Cancer Research 47, 5600-5606, Nov. 1, 1987.
LaBrecque et al., "Purification and Physical-Chemical Characterization of Hepatic Stimulator Substance," Hepatology, vol. 7, No. 1, 1987, pp. 100-106.
Yao et al., Chinese Med. J. 106:527-532 (1993).
Zhou et al., Chin. Med. Sci. J. 7:197-200 (1992).
He et al., Hepatology 17:225-229 (1993).
Hagiya et al., Proc. Natl. Acad. Sci. USA 91:8142-8146 (1994).

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