Mammalian augmenter of liver regeneration and variants thereof

Details Mammalian augmenter of liver regeneration and variants thereof Mammalian augmenter of liver regeneration and variants thereof

1996-06-12

1998-09-22

Grimes, Eric

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530350, 530399, A61K 3818, C07K 14475

Patent

active

058113975

ABSTRACT:
Full-length cDNA clones have been isolated encoding purified augmenter of liver regeneration (ALR) polypeptides prepared from the cytosol of livers from weanling rats and from humans. The full-length clone from the rat is a 1226 bp cDNA containing an 81 bp 5'-untranslated region, a 594 bp coding region and a 551 bp 3'-untranslated region. The coding region encodes three proteins with estimated molecular weights of 15,081, 20,193 and 22,835. The full-length clone from the human consists of a 727 bp cDNA containing a 4 bp 5'-untranslated region, a 615 bp coding region and a 108 bp 3'-untranslated region, including the termination codon TAG and the poly (A) region. The 615 bp coding region encodes four proteins, human ALR-V1, ALR-V2, ALR-V3 and ALR, having estimated molecular weights of 23,448, 20,834, 20,703 and 15,028, respectively.

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Hagiya et al., "Cloning and sequence analysis of the rat augmenter of liver regeneration (ALR) gene: Expression of biologically active recombinant ALR and demonstration of tissue distribution," Proc. Natl. Acad. Sci. USA, vol. 91, pp. 8142-8146, Aug. 1994 pp. 8142-8146.

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