Mammalian artificial chromosomes

Details Mammalian artificial chromosomes Mammalian artificial chromosomes

1991-09-13

1994-02-22

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

4351723, 4352402, 43524026, C12N 1506, C12N 1512, C12N 516, C12N 528

Patent

active

052886255

ABSTRACT:
Non-human cell lines are disclosed which contain functional centromeres comprising human DNA sequences linked to a dominant marker gene. The centromeres are carried on stable chromosomes which carry no centromeres other than those comprising human DNA sequences. The cell lines can be used to isolate the chromosomes as well as for use in inserting genes into mammalian cells. Methods are taught for generating such cell lines from cell lines carrying dicentric chromosomes.

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