Mammalian anoxia-responsive regulatory element

Details Mammalian anoxia-responsive regulatory element Mammalian anoxia-responsive regulatory element

1996-03-01

1997-10-28

Ketter, James

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving nucleic acid

435 911, 4351723, 435 691, 435353, 435375, 4353201, 536 241, C12Q 168

Patent

active

056817061

ABSTRACT:
Genetic regulatory elements which effect anoxic induction of a DNA molecule in mammalian cells exposed to anoxia are identified. The genetic regulatory elements, designated mammalian anoxia-responsive elements, when operably linked to a DNA molecule and basal promoter regulate the transcription of the DNA molecule in response to anoxia. The invention relates to recombinant vectors useful for introduction into mammalian cells, and the selective expression in mammalian cells exposed to anoxic conditions. Also provided are methods of using such vectors.

REFERENCES:
Anoxic Induction of a Sarcoma Virus-Related VL30 Retrotransposon is Mediated by a cis-acting Element Which Binds Hypoxia-Inducible Factor 1 and an Anoxia-Inducible Factor, Scott D. Estes et al., Journal of Virology, Oct. 1995, vol. 69, No. 10, pp. 6335-6341.
Firulli et al., J. Virol., vol. 67, 1993, pp. 6857-6862.
Wang et al., PNAS, vol. 90 1993, pp. 4304-4308.

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