Mammalian adrenocorticotropic hormone receptors and uses

Details Mammalian adrenocorticotropic hormone receptors and uses Mammalian adrenocorticotropic hormone receptors and uses

1995-06-07

1998-06-30

Chan, Christina Y.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 793, 436503, G01N 33567

Patent

active

057732299

ABSTRACT:
The present invention relates to a mammalian adrenocorticotropic hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian adrenocorticotropic hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian adrenocorticotropic hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian adrenocorticotropic hormone receptor. The invention also provides methods for screening ACTH.sup.R agonists and antagonists in vitro using preparations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the ACTH.sup.R receptor gene. The invention specifically provides human and bovine ACTH.sup.R genes.

REFERENCES:
Burch, R.M. (1991) J. Recept. Res. vol. 11(1-4):101-113.
Hanneman et al., 1987, "Peptides encoded by the pro-opiomelanocortin gene", in Peptide Hormone as Prohormones, G. Martinez, ed. (Ellis Horwood Ltd.: Chichester, UK) pp. 53-82.
DeWied & Jolles, 1982, "Neuropeptides derived from pro-opiocortin: Behavioral, physiological and neurochemical effects", Physiol. Rev. 62: 976-1059.
Oelofsen & Ramachandran, 1983, "Studies of corticotropin receptor on rat adipocytes", Arch. Biochem. Biophys. 225: 414-421.
Mertz & Catt, 1991, "Adrenocorticotropin receptors: Functional expression from rat adrenal mRNA in Xenopus laevis oocytes", Proc. Natl. Acad. Sci. USA 88:8525-8529.
Moore et al., 1991, "Allgrove syndrome: an autosomal recessive syndrome of ACTH insensitivity, achalasia and alacrima", Endocrinology 34: 107-114.

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