Mammalian adrenocorticotropic hormone receptors and uses

Details Mammalian adrenocorticotropic hormone receptors and uses Mammalian adrenocorticotropic hormone receptors and uses

1993-06-15

1996-09-10

Patterson, Jr., Charles L.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

C07K 14705, C07K 1471

Patent

active

055547290

ABSTRACT:
The present invention relates to a mammalian adrenocorticotropic hormone receptor. The invention is directed toward the isolation, characterization and pharmacological use of mammalian adrenocorticotropic hormone receptor, the gene corresponding to this receptor, a recombinant eukaryotic expression construct capable of expressing a mammalian adrenocorticotropic hormone receptor in cultures of transformed eukaryotic cells and such cultures of transformed eukaryotic cells that synthesize mammalian adrenocorticotropic hormone receptor. The invention also provides methods for screening ACTH.sup.R agonists and antagonists in vitro using preparations of receptor from such cultures of eukaryotic cells transformed with a recombinant eukaryotic expression construct comprising the ACTH.sup.R receptor gene. The invention specifically provides human and bovine ACTH.sup.R genes.

REFERENCES:
Hanneman et al., 1987, "Peptides encoded by the pro-opiomelanocortin gene", in Peptide Hormone as Prohormones, G. Martinez, ed. (Ellis Horwood Ltd.: Chichester, UK) pp. 53-82.
DeWied & Jolles, 1982, "Neuropeptides derived from pro-opiocortin: Behavioral, physiological and neurochemical effects", Physiol. Rev. 62:976-1059.
Oelofsen & Ramachandran, 1983, "Studies of corticotropin receptor on rat adipocytes", Arch. Biochem. Biophys. 225:414-421.
Mertz & Catt, 1991, "Adrenocorticotropin receptors: Functional expression from rat adrenal mRNA in Xenopus laevis oocytes", Proc. Natl. Acad. Sci. USA 88:8525-8529.
Moore et al., 1991, "Allgrove syndrome: an autosomal recessive syndrome of ACTH insensitivity, achalasia and alacrima", Endocrinlolgy 34: 107-114.
Clarke et al. (1990). Biochemical and Biophysical Research Communications, vol. 168, No. 3, pp. 1020-1026.
Bowman et al. (1980). Textbook of Pharmacology, Second Edition, p. 39.18.

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