Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1995-06-07
1998-12-08
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 26, 435 29, G01N 3353, C12Q 132, C12Q 102
Patent
active
058467343
ABSTRACT:
Mammalian adipogenic factors, including purified proteins or glycoproteins, capable of inducing the adipose differentiation of adipogenic cells are disclosed, as are antibodies to such proteins, DNA encoding the proteins and host cells expressing the proteins. A method for determining the susceptibility of a subject to obesity by measuring the levels of one or more adipogenic factors in a biological fluid or tissue extract is also disclosed, as is a method for evaluating an anti-obesity drug which comprises contacting the drug with cells capable of producing one or more adipogenic factors and measuring the amount of the factors produced.
REFERENCES:
patent: 5039619 (1991-08-01), Staple et al.
Serrero et al., "Differentiation of Newborn Rad Adipocyte Precursors in Defined Serum-free Medium", In Vitro Cell. Dev. Biol. 22, 63-66, 1987.
Swierczewski et al., "Characterization of rat preadipocytes from normal rat adipose tissue by their effector response", Biochem. J. 248, 383-387. 1987.
Flores-Delgado et al., "Thyroid hormone stimulates adipocyte differentiation of 3T3 cells", Mol. Cell. Biochem. 76, 35-43, 1987.
Kawashima et al., "Interleukin-11: A Novel Stroma-derived Cytokine", Progr. Growth Factor Res. 4, 191-206, 1992.
James Darnell et al., "Molecular Cell Biology," Scientific American Books, pp. 221-222, 260-262.
Gaillard et al., Biochim. Biophys. Acta., vol. 846, pp. 185-191, 1985.
C. Milstein et al., "Continous cultures of fused cells secreting antibody of predefined specificity," Nature, vol. 26, Aug. 7, 1975.
Zaitsu et al., J. Cellular Physiology, vol. 485-491 and vol. 49. pp. 339-346, 1991.
Hutzell Paula K.
W. Alton Jones Cell Science Center
Wortman Donna C.
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