Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1998-05-20
1999-10-19
Hutzell, Paula K.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 71, 435 72, 5303871, G01N 33574, G01N 3353, C07K 1600
Patent
active
059687541
ABSTRACT:
A purified and isolated DNA sequence and the encoded mammary-specific protein, mammaglobin, are disclosed. Also disclosed are methods for the detecting breast cancer based upon the overexpression and secretion of mammaglobin by breast cancer cells. The methods detect and/or quantitate the presence of mammaglobin or the mRNA encoding mammaglobin.
REFERENCES:
patent: 5668267 (1997-09-01), Watson et al.
patent: 5855889 (1999-01-01), Watson et al.
Bjork et al, Partial Characterization and "Quantitation" of a Human Prostatic Estramustine-binding Protein, Cancer Res. 42:1935-1942 (1982).
Bjork et al., Expression and Partial Characterization of Estramustine-Binding Protein (EMBP) in Human Breast Cancer and Malignant Melanoma, Anticancer Res. 11:1173-1182 (1991).
Cato et al., The Hormonal Regulation of Uteroglobin Gene Expression, Anticancer Res. 5:65-72 (1985).
Miele et al., Uteroglobin: Structure, Molecular Biology, and New Perspectives on Its Function as a Phospholipase A.sub.2 Inhibitor, Endocrine Rev 8:474-490 (1987).
Miele et al., Uteroglobin and uteroglobin-like proteins: The uteroglobin family of proteins, J. Endocrinol. Invest. 17:679-692 (1994).
Parker et al., Prostatic Steroid-binding Protein, J. Biol. Chem. 258:12-15 (1983).
Parker et al., Organization and Expression of Prostatic Steroid Binding Protein Genes, J. Steroid Biochem. 20:67-71 (1984).
Parker et al., Organization and Expression of Genes Encoding Prostatic Steroid Binding Protein, Ann N.Y. Acad., Sci. 438:115-124 (1984).
Peeters et al., Structural Studies on Rat Prostatic Binding Protein, Eur. J. Biochem. 115:115-121 (1981).
Peri et al., Tissue-specific Expression of the Gene Coding for Human Clara Cell 10-kD Protein, a Phospholipase A.sub.2 -inhibitory Protein, J. Clin. Invest. 92:2099-2109 (1991).
Watson et al., Isolation of Differentially Expressed Sequence Tags from Human Breast Cancer, Cancer Res. 54:4598-4602 (1994).
Fleming Timothy P.
Watson Mark A.
Hutzell Paula K.
Sun-Hoffman Lin
Washington University
LandOfFree
Mammaglobin, a mammary-specific breast cancer protein does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Mammaglobin, a mammary-specific breast cancer protein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Mammaglobin, a mammary-specific breast cancer protein will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2054501