Malonic acid derivatives having antiadhesive properties

Details Malonic acid derivatives having antiadhesive properties Malonic acid derivatives having antiadhesive properties

1995-03-13

1997-12-02

Peselev, Elli

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

514574, 536 41, 562400, 562590, A61K 3119, A61K 3170, C07C 5500, C07H 1500

Patent

active

056936214

ABSTRACT:
The invention relates to malonic acid derivatives, which inhibit the binding of selectin to carbohydrate ligands, and pharmaceutical compositions and diagnostic agents containing these derivatives, and methods for using these pharmaceutical compositions and diagnostic agents.

REFERENCES:
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Takada et al. "Enzymatic Preparation of Enantiomerically Pure (1R,2R)-and (1S,2S)-2-Aminocyclohexanols", Bull. Chem. Soc. Jpn., 67:1196-1197 (1994).
Lowe et al. "ELAM-1-Dependent Cell Adhesion to Vascular Endothelium Determined by a Transfected Human Fucosyltransferase cDNA", Cell, 63:475-484 (1990).
Reutter et al. "Biological Significance of Sialic Acids", Cell Biology Monographs, 263-305 (1982).

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