Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-03-22
2008-09-16
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S522000
Reexamination Certificate
active
07425551
ABSTRACT:
The invention relates to malonamide derivatives of formulawhereinA1, A2, R1, R2, R3, and R4are as defined herein and to pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof for the treatment of Alzheimer's disease.
REFERENCES:
patent: WO 01/77086 (2001-10-01), None
patent: WO 01/92235 (2001-12-01), None
patent: WO 2004/069826 (2004-08-01), None
patent: WO 2005/023772 (2005-03-01), None
patent: WO 2005/040126 (2005-05-01), None
Sisodia et al., Nature Reviews/Neuroscience vol. 3, Apr. 2002, pp. 281-290.
Beher et al., Biochemical Society Transactions (2002), vol. 30, Part 4, pp. 534-537.
Wolfe M., Current Topics in Medicinal Chemistry, 2002, 2, pp. 371-383.
Tsai et al., Current Medicinal Chemistry, 2002, col. 9, No. 11, pp. 1087-1106.
Sambamurti et al., Drug Development Research, vol. 56, 2002, pp. 211-227.
May, P.C., Drug Discovery Today, vol. 6, No. 9, May 2001, pp. 459-462.
Nunan et al., FEBS Letters, 483 (2000) pp. 6-10.
Hardy et al., Science vol. 297, 2002, pp. 353-356.
Wolfe M., Journal of Medicinal Chemistry, vol. 44, No. 13 (2001) pp. 2039-2060.
Brockhaus, et al., Neuroreport 9(7) pp. 1481-1486 (1998).
Flohr Alexander
Jakob-Roetne Roland
Wostl Wolfgang
Hoffmann-La Roche Inc.
Johnston George W.
Kifle Bruck
Prior Kimberly J.
Rocha-Tramaloni Patricia S.
LandOfFree
Malonamide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Malonamide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Malonamide derivatives will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3991154