Malonamide derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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Details

C540S522000

Reexamination Certificate

active

07425551

ABSTRACT:
The invention relates to malonamide derivatives of formulawhereinA1, A2, R1, R2, R3, and R4are as defined herein and to pharmaceutically acceptable acid addition salts, optically pure enantiomers, racemates or diastereomeric mixtures thereof for the treatment of Alzheimer's disease.

REFERENCES:
patent: WO 01/77086 (2001-10-01), None
patent: WO 01/92235 (2001-12-01), None
patent: WO 2004/069826 (2004-08-01), None
patent: WO 2005/023772 (2005-03-01), None
patent: WO 2005/040126 (2005-05-01), None
Sisodia et al., Nature Reviews/Neuroscience vol. 3, Apr. 2002, pp. 281-290.
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Wolfe M., Current Topics in Medicinal Chemistry, 2002, 2, pp. 371-383.
Tsai et al., Current Medicinal Chemistry, 2002, col. 9, No. 11, pp. 1087-1106.
Sambamurti et al., Drug Development Research, vol. 56, 2002, pp. 211-227.
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Nunan et al., FEBS Letters, 483 (2000) pp. 6-10.
Hardy et al., Science vol. 297, 2002, pp. 353-356.
Wolfe M., Journal of Medicinal Chemistry, vol. 44, No. 13 (2001) pp. 2039-2060.
Brockhaus, et al., Neuroreport 9(7) pp. 1481-1486 (1998).

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