Malonamide derivatives

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S212070, C514S221000, C514S450000, C540S517000, C540S522000, C540S523000, C549S354000

Reexamination Certificate

active

10767784

ABSTRACT:
The invention relates to malonamide derivatives of formulawherein each of the variables are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The compounds are γ-secretase inhibitors. Thus, the invention also relates to pharmaceutical compositions containing these compounds and to a method of treating Alzheimer's disease by administering the compounds of the invention.

REFERENCES:
patent: 6759404 (2004-07-01), Olson et al.
patent: 7160875 (2007-01-01), Flohr et al.
patent: WO 93/03011 (1993-02-01), None
patent: WO 01/27091 (2001-04-01), None
patent: WO01/77086 (2001-10-01), None
patent: WO 01/77086 (2001-10-01), None
Sisodia, S., et al.,Nature Reviews/Neuroscience, vol. 3, Apr. 2002, pp. 281-290.
Wolfe, M. S.,Current topics in Medicinal Chem., 2002, vol. 2, pp. 371-383.
Tsai, J., et al.,Current Medicinal Chemistry, 2002, vol. 9, No. 11, pp. 1087-1106.
Sambamurti, K., et al.,Drug Development Research, vol. 56, 2002, pp. 211-227.
May, P. C.,Drug Discovery Today, vol. 6, No. 9, May 2001, pp. 459-462.
Nunan, J. et al.,FEBS Letters, vol. 483, 2000, pp. 6-10.
Hardy, J. et al.,Science, vol. 297, Jul. 19, 2002, pp. 353-356.
Wolfe, M. S.,Journ. Of Medicinal Chemistry, vol. 44, No. 13, 2001, pp. 2039-2060.
Li, Y. et al.,PNAS, vol. 97(11), 2000, pp. 6138-6143.
Brockhaus, M. et al.,Neuro Report, vol. 9(7), 1998, pp. 1481-1486.
H.F. Dovey et al, Journal of Neurochemistry, vol. 76, No. 1, pp. 173-181 (2001).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Malonamide derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Malonamide derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Malonamide derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3947094

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.