Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2007-05-01
2007-05-01
Kifle, Bruck (Department: 1624)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C540S491000
Reexamination Certificate
active
11289176
ABSTRACT:
The invention relates to compounds of the formula IwhereinR, R1, R2, R3, X, andn are defined in the specification. The invention also provides pharmaceutically suitable acid addition salts thereof and all forms of optically pure enantiomers, recemates or diastereomers and diastereomeric mixtures thereof. Compounds of the invention are useful for the treatment of Alzheimer's disease.
REFERENCES:
patent: WO 01/90084 (2001-11-01), None
patent: WO 2004/069826 (2004-08-01), None
patent: WO 2004/100958 (2004-11-01), None
patent: WO 2005/023772 (2005-03-01), None
patent: WO 2005/040126 (2005-05-01), None
Haass, C., The EMBO Journal (2004), 23, pp. 483-488.
Fraering, et al., Biochemistry (2004), 43 (30), pp. 9774-9789.
Sisodia, et al. Nature Reviews/Neuroscience, vol. 3, (Apr. 2002) pp. 281-290.
Beher et al., Biochemical Society Transactions (2002), vol. 30. part 4, pp. 534-537.
Wolfe, M., Current Topics in Medicinal Chemistry, 2002, 2, 371-383.
Tsai, et al., Current Medicinal Chemistry, 2002, vol. 9, No. 11, 1087-1106.
Sambamurti et al., Drug Development Research, 56, 211-227, 2002.
May, P., Drug Discovery Today, vol. 6, No. 9, May 2001, 459-462.
Nunan, et al., FEBS Letters, 483, (2000), 6-10.
Hardy, et al., Science, vol. 297, 353-356, Jul. 2002.
Wolfe, M., Journ. of Medicinal Chemistry, vol. 44, No. 13, 2001, 2039-2060.
Brockhaus et al., Neuroreport 9(7) 1481-1486 (1998).
Itoh, et al., Chem. Pharm. Bull. 1986, 34(3) p. 1128-1147.
Herreman et al., Nature Cell Biology 2, 461-462, 2000.
De Stropper et al., Nature 398, 518-522, 1999.
Chung et al., Nature Cell Biology 3, 1129-1132, 2001.
Hadland et al., PNAS 98, 7487-7491, 2001.
Ferrando et al., Cancer Cell 1, 75-87, 2002.
Weng et al., Science 306, 269-271, 2004.
Weng et al., Mol Cell Biol 23, 655-664, 2003.
Weijzen et al., Nature Medicine 8, 979-986, 2002.
Nickoloff et al., Oncogene 22, 6598-6608, 2003.
Li et al., PNAS 97(11) 6138-6143, 2000.
Flohr Alexander
Jakob-Roetne Roland
Wostl Wolfgang
Hoffmann-La Roche Inc.
Johnston George W.
Kifle Bruck
Prior Kimberly J.
Rocha-Tramaloni Patricia S.
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