Mallory body specific monoclonal antibody and process for produc

Details Mallory body specific monoclonal antibody and process for produc Mallory body specific monoclonal antibody and process for produc

1984-08-22

1987-08-25

Warren, Charles F.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

435 68, 435 70, 4351722, 935104, 530387, C07K 1504, C12N 500

Patent

active

046892982

ABSTRACT:
There is disclosed a process for preparing anti-NMB-1 from Mallory bodies wherein Mallory bodies are removed and isolated from a liver and Mallory antibodies are produced by hybridoma techniques followed by isolation of the anti-NMB-1 having two polypeptide components of 45 and 66 kd by Western blotting.

REFERENCES:
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Morton, J. A. et al, J. Pathology, vol. 131(3), pp. 275-276 (1980), Cited in Bio. Abstract 20048097.
Burns, J. et al, J. Clin. Pathol., vol. 36(7), pp. 751-755 (1983), cited in Bio. Abstract 77007757.
Sameshima, Y. et al, Hepatology, vol. 4(5), p. 1084 (1984), cited in Bio. Abstract 28044535.
Luisada-Opper et al, Chemical Nature of Alcoholic Hyalin, Gastroenterology 73:1374-1376, 1977.
Zetterman et al, Alcoholic Hepatitis, Gastroenterology 70:382-384, 1976.
Kanagasundaram et al, Immunologic Aspects of Liver Disease, Medical Clinics of North America, vol. 63, No. 3, May 1979, pp. 631-642.
McGee et al, Monoclonal Antibodies in Clinical Medicine, London Academic Press, 1982:431-455.
Leevy, et al, Immunologic Aspects of Liver Disease of the Alcoholic, Research Advances in Alcohol and Drug Problems, vol. 6, Plenum Publishing Corporation, 1981, pp. 255-280.
Sorrell et al, Lymphocyte Transformation and Alcoholic Liver Injury, Gastroenterology, vol. 63, No. 6 (1972), pp. 1020-1025.

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