Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reissue Patent
2007-04-24
2007-04-24
Azpuru, Carlos (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
C424S426000
Reissue Patent
active
10843658
ABSTRACT:
The invention is directed toward a malleable bone putty and a flowable gel composition for application to a bone defect site to promote new bone growth at the site which comprises a new bone growth inducing compound of demineralized lyophilized allograft bone powder. The bone powder has a particle size ranging from about 100 to about 850 microns and is mixed in a high molecular weight hydrogel carrier, the hydrogel component of the carrier ranging from about 0.3 to 3.0% of the composition and having a molecular weight of about at least 10,000 Daltons. The composition contains about 25% to about 40% bone powder and can be additionally provided with BMP's and a sodium phosphate buffer.
REFERENCES:
patent: 2621145 (1952-12-01), Sano
patent: 2968593 (1961-01-01), Rapkin
patent: 4172128 (1979-10-01), Thiele et al.
patent: 4191747 (1980-03-01), Scheicher
patent: 4595713 (1986-06-01), St. John
patent: 4610692 (1986-09-01), Eitenmuller et al.
patent: 4619995 (1986-10-01), Hayes
patent: 4637931 (1987-01-01), Schmitz
patent: 5073373 (1991-12-01), O'Leary et al.
patent: 5290558 (1994-03-01), O'Leary et al.
patent: 5314476 (1994-05-01), Prewett et al.
patent: 5356629 (1994-10-01), Sander et al.
patent: 5507813 (1996-04-01), Dowd et al.
patent: 5516532 (1996-05-01), Atala et al.
patent: 5707962 (1998-01-01), Chen et al.
patent: 5830493 (1998-11-01), Yokota et al.
patent: 6030635 (2000-02-01), Gertzman et al.
patent: 6124273 (2000-09-01), Drohan et al.
patent: 0 522569 (1993-01-01), None
patent: 0 784985 (1997-07-01), None
patent: WO 98/14222 (1998-04-01), None
patent: WO 99/11298 (1999-03-01), None
patent: WO 99/52572 (1999-10-01), None
D. Cram and G. Hammond, The Carbohydrates II, pp. 43-55, 1974.
M. Iwata and M. Urist, Protein Polysaccaride of Bone Morphogenetic Matrix, “Clinical Orthopeadics and Related Research, N. 87”, pp. 257-273 (Sep. 1972).
Klokkevold et al., Osteogenesis Enhanced by Chitosan (Poly-N-Acetyl Glucosaminoglycan) In Vitro Periodontol (1996) 67:1170 1175.
Pillioni et al., Low Molecular Weight Hyaluronic Acid Increases Osterogenesis in vitro, 1992, J. Dent. Res. 71 (IADR Abstracts).
Rubin, M.D., Leonard R., F.A.C.S., Biomaterials in Reconstructive Surgery, p. 314 (1983).
Sasaki, et al., Stimlulation of Osteroinduction in Bone Wound Healing by High-Molecular Hyaluronic Acid Bone, vol. 16 No. 1 (Jan. 1995).
Gertzman Arthur A.
Sunwoo Moon Hae
Azpuru Carlos
Gipple & Hale
Hagopian Casey
Hale John S.
Musculoskeletal Transplant Foundation
LandOfFree
Malleable paste for filling bone defects does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Malleable paste for filling bone defects, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Malleable paste for filling bone defects will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3720748