Malignant cell type markers of the interior nuclear matrix

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 71, 436 63, 436 64, 5303877, 5303888, G01N 33574, G01N 3353, G01N 3348, C07K 1600

Patent

active

058828761

ABSTRACT:
Disclosed are genetic sequences and their encoded amino acid sequences for two interior nuclear matrix proteins useful as markers of malignant cell types. Primary and secondary structure analysis of the proteins is presented as well as means for their recombinant production, and compositions and methods for the use of these markers in clinical assays and cancer therapies.

REFERENCES:
patent: 4806463 (1989-02-01), Goodchild et al.
patent: 4885236 (1989-12-01), Penman et al.
patent: 5098890 (1992-03-01), Gewirtz et al.
patent: 5273877 (1993-12-01), Fey et al.
Salden et al., "Anti-nuclear matrix antibodies in mixed connective tissue disease" (1982) Eur. J. of Immunology, 12:783-786.
Seaver, "Monoclonal Antibodies in Industry: More Difficult Than Originally Thought" (1994) Gen. Engineering News, 14(14):10 and 21.
News Release; "Clinical Utility of Matritech's Bladder Cancer Test Reported in August Issue of Journal of Urology"; Jul. (1996).
Keesee, et al.; "Utilization of Nuclear Matrix Proteins for Cancer Diagnosis"; Critical Reviews in Eukaryotic Gene Expression; 6(2&3):189-124 (1996).
Todorov, et al.; "Detection of the 125-kDa Nuclear Protein Mitotin in Centrosomes, the Poles of the Mitotic Spindle, and the Midbody"; Experimental Cell Research; 199:398-401 (1992).
Tousson, "Centrophilin: A Novel Mitotic Spindle Protein Involved in Microtubule Nucleation"; The J. of Cell Biology; 112 (No. 3):427-440 (1991).
Whitfiled et al.; "Cloning of a Gene Encoding an Antigen Associated with the Centrosome in Drosophila"; J. of Cell Science; 89:467-480 (1988).
Kallajoli et al.; "Ability to Organize Microtubules in Taxol-Treated Mitotic PtK.sub.2 Cells Goes with the SPN Antigen and Not With the Centrosome"; J. of Cell Science; 102:91-102 (1992).
Nickerson et al.; "A Normally Masked Nuclear Matrix Antigen That Appears at Mitosis on Cytoskeleton Filaments Adjoining Chromosomes, Centrioles, and Midbodies"; The J. of Cell Biology; 116 (No. 4):977-987 (Feb. 1992).
Stuurman et al.; "A Monoclonal Antibody Recognizing Nuclear Matrix-Associated Nuclear Bodies"; J. of Cell Science; 101:773-784 (1992).
Yang et al.; "The Nuclear-Mitotic Apparatus Protein is Important in the Establishment and Maintenance of the Bipolar Mitotic Spindle Apparatus"; Molecular Biology of the Cell; 3:1259-1267 (Nov. 1992).
Maekawa et al.; "Identification of a Minus End-Specific Microtubule-Associated Protein Located at the Mitotic Poles in Cultured Mammalian Cells"; European J. of Cell Biology; 54:255-267 (1991).
Thibodeau et al.; "Monoclonal Antibody CC-3 Recognizes Phosphoproteins in Interphase and Mitotic Cells"; Experimental Cell Research; 195:145-153 (1991).
Kallajoki, et al.; "A 210 kD nuclear matrix protein is a functional part of the mitotic spindle; a microinjection study using SPN monoclonal antibodies;" EMBO J.; 10:3351-3362 (1991).
Briggman et al.; "Detection of nuclear matrix protein in the urine of patients with transitional cell carcinoma," poster presented at NCI Conference on Chemoprevention of Premalignant and Early Malignant Lesions of the Bladder, Toas, New Mexico, Jul. 29-Aug. 2, 1992.
Compton, et al., "Identification of Novel Centromere/Kinetochore-associated Proteins Using Monoclonal Antibodies Generated Against Human Mitotic Chromosome Scaffolds"; The J. of Cell Biology; 112 (No. 6):1083-1097 (Mar. 1991).
Harlow et al. (1988) "Antibodies: A Laboratory Manual," Cold Spring Harbor Laboratory, p. 27.
Miller et al., "Release of Nuclear Matrix Proteins During Apoptotic Cell Death", J. Cell Biology, 115:314A (1991) (Abstract).
Miller et al., "Detection of Nuclear Matrix Proteins in Serum From Cancer Patients", Cancer Research, 52(2):422-427 (1992).
Sambrook et al., "Molecular Cloning", Cold Spring Harbor Lab Press, p. 739 (1989).
Oeller et al., "Rev. Inhibition of Tom. Fruit Senescence by Antisense RNA", Science, 254:437-439 (Oct. 1991).
Compton et al., J. of Cell Biology, 116:No. 6, 1395-1408, (Mar. 1992).
Fey et al., Critical Reviews, 1:Issue 2, 127-143, (1991).
Yang et al., J. of Cell Biology, 116:No. 6, 1303-1317 (Mar. 1992).
Lyderson et al., Cell, 22:489-492, (Nov. 1980).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Malignant cell type markers of the interior nuclear matrix does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Malignant cell type markers of the interior nuclear matrix, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Malignant cell type markers of the interior nuclear matrix will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-816452

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.