Maldi/LDI time-of-flight mass spectrometer

Details Maldi/LDI time-of-flight mass spectrometer Maldi/LDI time-of-flight mass spectrometer

1998-03-17

1999-10-19

Nguyen, Kiet T.

Radiant energy

Ionic separation or analysis

Ion beam pulsing means with detector synchronizing means

H01J 4840

Patent

active

059693509

ABSTRACT:
A matrix-assisted laser desorption ionization/laser desorption ionization (MALDI/LDI) time-of-flight mass spectrometer (TOF-MS) which includes an ion source employing a ground voltage configuration. The improved MALDI/LDI TOF-MS includes a laser for ablating a sample positioned within a gridless source. The ionized sample is then repelled through a floating flight tube toward a detector and within a vacuum chamber. The floating flight tube allows a lower than conventional voltage to be applied to the ions. A digital camera is provided for viewing a sample when positioned in the vacuum ready for analysis. The sample image is displayed on the control computer monitor and is available for computer analysis and instrumentation control, including external instrumentation such as that involved in sample preparation and handling. A sample plate and sample changer are referenced at ground voltage, thus allowing the sample plate to define a relatively large configuration, such as one defining a microtiter sample receptor matrix of 8.times.12. A work shelf is provided for use of an operator and is disposed proximate an opening to the sample changer, and, to this extent, defines a sample plate entry. While being convenient to the operator for loading and unloading samples, the configuration of the work shelf and sample changer also facilitates interfacing with robotic sample handling equipment.

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