Malate dehydrogenase method

Details Malate dehydrogenase method Malate dehydrogenase method

1983-04-27

1986-05-27

Kepplinger, Esther M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving oxidoreductase

435184, C12Q 132, C12N 999

Patent

active

045915555

ABSTRACT:
A method of detection of neoplastic tissue comprising, providing a first solution, the first solution comprising cytosol malate dehydrogenase from a mammalian test tissue, determining a first rate or a first function of the first rate at which the first solution catalyzes the reaction of oxaloacetate to malate, comparing the first rate or first function of the first rate with a known standard normal rate or function of the normal rate at which a normal solution of cytosol malate dehydrogenase catalzes the reaction of oxaloacetate to malate, whereby the first rate or the first function of the first rate being substantially higher than the known standard normal rate or function of the normal rate indicated that the mammalian test tissue is neoplastic.

REFERENCES:
patent: 4311791 (1982-01-01), Bernstein

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