Multicellular living organisms and unmodified parts thereof and – Method of using a transgenic nonhuman animal in an in vivo...
Reexamination Certificate
2007-09-25
2007-09-25
Kaushal, Sumesh (Department: 1633)
Multicellular living organisms and unmodified parts thereof and
Method of using a transgenic nonhuman animal in an in vivo...
C800S008000, C800S009000, C800S013000, C800S014000, C800S018000, C800S021000
Reexamination Certificate
active
11207176
ABSTRACT:
The present invention features a non-human animal model of malaria, e.g.,Plasmodium, particularlyPlasmodium falciparum. The model is based on a non-human, immunocompromised transgenic animal having a human-mouse chimeric liver, where the transgene provides for expression of a urokinase-type plasminogen activator in the liver. The invention also features methods for identifying candidate therapeutic agents, e.g., agents having anti-pathogenic activity against malaria.
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Azad Abdu F.
Elliott John F.
Kneteman Norman M.
Sacci, Jr. John B.
Tyrrell D. Lorne
Bozicevic Field & Francis LLP
Francis Carol L.
Kaushal Sumesh
KMT Hepatech, Inc.
University of Maryland Baltimore
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