Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Reexamination Certificate
2008-01-03
2010-02-02
Graser, Jennifer E (Department: 1645)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
C424S185100, C424S269100, C530S350000
Reexamination Certificate
active
07655247
ABSTRACT:
The invention provides isolated placentalP. falciparumpolypeptides comprising an amino acid sequence selected from the group consisting of SEQ ID NOs:1-4 and 6-24, and immunogenic derivatives thereof. The invention also provides isolated nucleic acid molecules encoding the placentalP. falciparumpolypeptides of the invention, compositions comprising one or more placentalP. falciparumpolypeptides of the invention, methods for inducing an immune response against the placentalP. falciparumpolypeptides, and methods for treating and diagnosing placental malaria.
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Wood (Guide to Molecular Cloning Techniques. vol. 152. 1987. Section IX. Chapter 49, pp. 443-457).
Duffy & Fried (2003) Antibodies that inhibitPlasmodium falciparumadhesion to chondroitin sulfate A are associated with increased birth weight and the gestational age of newborns, Infect. Immun. 71:6620-3.
Duffy et al. (2005) Malaria vaccines: using models of immunity and functional genomics tools to accelerate the development of vaccines againstPlasmodium falciparum,Vaccine 23:2235-42.
Fried et al. (2004) Mass spectrometric analysis ofPlasmodium falciparumerythrocyte membrane protein-1 variants expressed by placental malaria parasites, Proteomics 4:1086-93.
Gardner et al. (2002) Genome sequence of the human malaria parasitePlasmodium falciparum,Nature 419:498-511.
Hall et al. (2002) Sequence ofPlasmodium falciparumchromosomes 1, 3-9 and 13, Nature 419:527-31.
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Duffy Patrick E.
Francis Susan
Fried Michal
Mutabingwa Theonest K.
Oleinikov Andrew
Blochlinger Karen
Graser Jennifer E
Seattle Biomedical Research Institute
The United States of America as represented by the Army
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