Malaria vaccine

Details Malaria vaccine Malaria vaccine

2006-07-18

2006-07-18

Housel, James (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

C424S185100, C424S191100, C424S272100, C435S069100, C435S069300

Reexamination Certificate

active

07078043

ABSTRACT:
A non-naturally occurring variant of a C-terminal fragment of aPlasmodiummerozoite surface protein-1 (MSP-1) wherein said variant has (i) a reduced affinity, compared with a naturally occurringPlasmodiumMSP-119, for at least one first antibody capable of blocking the binding of a second antibody, which second antibody inhibits the proteolytic cleavage ofPlasmodiumMSP-142and (ii) substantially the same affinity for at least one third antibody compared with said naturally occurringPlasmodiumMSP-119. which third antibody inhibits the proteolytic cleavage ofPlasmodiumMSP-142is provided for use in an anti-malarial vaccine.

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