Malaria vaccine

Details Malaria vaccine Malaria vaccine

1981-02-12

1984-08-21

Tanenholtz, Alvin E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

435 68, 4351722, 4351723, 424 88, 935108, 935 65, 935 45, 935 6, 935 22, C07G 700, C12P 2100, C12N 1500

Patent

active

044669178

ABSTRACT:
The present invention provides antisera and monoclonal antibodies directed against the sporozoite stage of the malaria parasite capable of providing protection against infection in both animals and humans. The invention further provides a purified antigen derived from sporozoites of the malaria parasite, the antigen being suitable for use as a vaccine against malarial infections in both animals and humans. The invention further provides means for preparing said antigen and a vaccine comprising said antigen.

REFERENCES:
Helling et al., Genetic Engineering, by Chakrabanty, CRC Press Inc., pp. 1-30, (1978).
Cohen, Nature, vol. 288, p. 8, Nov. 6, 1980.
Yoshida et al., Science, vol. 207, pp. 71-73, Jan. 4, 1980.
Nandin et al., Nature, vol. 274, pp. 55-57, Jul. 6, 1978.
Todorovic et al., The American Journal of Tropical Medicine and Hygiene, vol. 17, No. 5, pp. 685-694, (1968).
Musoki et al., The Journal of Parasitology, vol. 63, No. 6, pp. 1081-1088, Dec. 1977.
Jepsen et al., Acts Path. Microbiol. Scand., Sect. C, vol. 88, pp. 263-270, (1980).
"Structural Similarities among the Protective Antigens of Sporozoites from Different Species of Malaria Parasites," by Ferricio Santoro, Alan H. Cochrane, Victor Nussenzweig, Elizabeth H. Nardin, Ruth S. Nussenzweig, Robert W. Gwadz, and Arturo Ferreira, The Journal of Biological Chemistry, vol. 258, pp. 3341-3345, Mar. 10, 1983.
"Circumsporozoite Proteins of Human Malaria Parasites Plasmodium Falciparum and Plasmodium Vivax," by Elizabeth H. Nardin, Victor Nussenzweig, Ruth S. Nussenzweig, William E. Collins, K. Tranakchit Harinasuta, Pramuan Tapchaisri, and Yaovamarn Chomcharn, J. Exp. Med., vol. 156, pp. 20-30, Jul. 1982.
"Cloning and Expression in E. coli of the Malarial Sporozoite Surface Antigen Gene from Plasmodium Knowlesi," by Joan Ellis, Luiz S. Ozaki, Robert W. Gwadz, Alan H. Cochrane, Victor Nussenzweig, Ruth S. Nussenzweig and G. Nigel Godson, Nature, vol. 302, pp. 536-538, (Apr. 7, 1983).
"Identification and Chemical Synthesis of a Tandemly Repeated Immunogenic Region of Plasmodium knowlesi Circumsporozoite Protein," by G. N. Godson, J. Ellis, P. Svec, D. H. Schlesinger & V. Nussenzweig, Nature, vol. 305, pp. 29-33, (Sep. 1, 1983).
"Monoclonal Antibodies Identify the Protective Antigens of Sporozoites of Plasmodium knowlesi," by Alan H. Cochrane, Ferrucio Santoro, Victor Nussenzweig, Robert W. Gwadz, and Ruth S. Nussenzweig, Proc. Natl. Acad. Sci. U.S.A., vol. 79, pp. 5651-5655, Sep. 1982.

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