Malaria immunogen and vaccine

Details Malaria immunogen and vaccine Malaria immunogen and vaccine

2005-09-13

2005-09-13

Housel, James (Department: 1648)

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Parasitic organism or component thereof or substance...

C424S184100, C424S204100, C424S227100, C424S272100, C530S350000, C530S403000

Reexamination Certificate

active

06942866

ABSTRACT:
A chimeric, carboxy-terminal truncated hepatitis B virus nucleocapsid protein (HBc) is disclosed that contains an immunogen for inducing the production of antibodies to malarial proteins. An immunogenic malarial epitope is expressed between residues 78 and 79 of the HBc immunogenic loop sequence. The chimer preferably contains a malaria-specific T cell epitope and is preferably engineered for both enhanced stability of self-assembled particles and enhanced yield of those chimeric particles. Methods of making and using the chimers are also disclosed.

REFERENCES:
patent: 4818527 (1989-04-01), Thornton et al.
patent: 4882145 (1989-11-01), Thornton et al.
patent: 4886782 (1989-12-01), Good et al.
patent: 5143726 (1992-09-01), Thornton et al.
patent: 5614194 (1997-03-01), Colman et al.
patent: 5928902 (1999-07-01), De Wilde et al.
patent: 6231864 (2001-05-01), Birkett
patent: 3741183 (1988-09-01), None
patent: WO 98/31382 (1998-07-01), None
patent: WO 99/40934 (1999-08-01), None
patent: WO 00/32625 (2000-06-01), None
patent: WO 01/27281 (2001-04-01), None
patent: WO 01/98333 (2001-12-01), None
patent: WO 02/13765 (2002-02-01), None
patent: WO 02/14478 (2002-02-01), None
Kratz et al., “Native display of complete foreign protein domains on the surface of hepatitis B virus capsids,” Proc. Natl. Acad. Sci. USA, vol. 96, pp. 1915-1920 (1999).
Nardin et al., “Conserved Repetitive Epitope Recognized by CD4= Clones from a Malaria-Immunized Volunteer,” Science, vol. 246, pp. 1603-1606 (1989).
Metzger et al., “Proline-138 is essential for the assembly of hepatitis B virus core protein,” Journal of General Virology, vol. 79, pp. 587-590 (1998).
Schodel et al., “Immunity to MAlaria Elicited by Hybrid Hepatits B Virus COre PArticles Carrying Circumsporozoite Protien Epitopes,” Journal of Experimental Medecine, vol. 180, pp. 1037-1046 (1994).
Pumpens et al., “Hepatitis B Core Particles as Epitope Carriers, ” Intervirology, vol. 38, pp. 63-74 (1995).
Marlar, T., et al.,Trans R. Soc. Trop. Med. Hyg.,(1995) 89(3): p. 307-308.
Garg et al.,Trans. R. Soc Trop. Med. Hyg.,(1995) 89(6): p. 656-657.
Baird et al.,Am. J. Trop. Med. Hyg.,(1991) 44(5): p. 547-552.
Baird et al.,Trans R Soc Trop Med Hyg,(1996) 90(4): p. 409-411.
Baird et al.,J. Infect. Dis.,(1995) 171(6): p. 1678-1682.
Murphy et al.,Lancet,(1993) 341(8837): p. 96-100.
Schwartz et al., [letter].N. Engl. J. Med.,(1991) 324(13): p. 927.
Rieckmann et al.,Lancet,(1989) 2(8673): p. 1183-1184.
Charoenlarp et al.,Southeast Asian J. Trop. Med. Public Health,(1973) 4(1): p. 135-137.
Krotoski,[letter]. N. Engl. J. Med.,(1980) 303(10): p. 587.
Schuurkamp et al.,Trans. R. Soc. Trop. Med. Hyg.,(1992) 86(2): p. 121-122.
Good, et al.,Anu. Rev. Immunol.,(1998) 16: p. 57-87.
Clyde et al.,Am. J. Med. Sci.,(1973) 266(6): p. 398-403.
Rieckmann et al.,Trans. R. Soc. Trop. Med. Hyg.,(1974) 68(3): p. 258-259.
Zavala et al.,Science,(1985) 228(4706): p. 1436-40.
Nussenzweig et al., Ciba Found. Symp., (1986) 119: p. 150-163.
Etlinger et al.,Immunology,(1988) 64(3): p. 551-558.
Etlinger et al.,J. Immunol.,(1988) 140(2): p. 626-633.
Herrington et al.,Nature,(1987) 328(6127): p. 257-259.
Ballou et al.,Lancet,(1987) 1(8545): p. 1277-1281.
Good et al.,Science,(1987) 235(4792): p. 1059-62.
Calvo-Calle et al.,J. Immunol.,(1993) 150(4): p. 1403-1412.
Moreno et al.,Int. Immunol.,(1991) 3(10): p. 997-1003.
Stoute et al.,N. Engl. J. Med.,(1997) 336(2): p. 86-91.
Stoute et al.,J.Infect Dis.(Oct. 1998) 178(4): 1139-44.
Milich et al.,Science,(1986) 234(4782): p. 1398-1401.
Herrington et al.,Am J Trop Med Hyg.(1991) 45(6): p. 695-701.
Schodel et al.,Behring Inst. Mitt.(1997) (98): p. 114-119.
Hoffman et al.,Nat. Med.(1997) 3(1):80-83.
Conway et al.,Nature,(1997) 386:91-94.
Bottcher et al.,Nature,(1997) 386:88-91.
Zheng et al., J.Biol. Chem.,(1992) 267(13):9422-9429.
Birnbaum et al.,J.Virol.(1990) 64, 3319-3330.
Clarke et al., F. Brown et al. eds.Vaccines(1991) 91, Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, pp. 313-318.
Seifer et al.,Intervirology(1995) 38:47-62.
Gallina et al.,J. Virol.(1989) 63:4645-4652.
Inada et al.,Virus Res.,(1989) 14:27-48.
Maassen et al.,Arch. Virol.(1994) 135:131-142.
Schodel et al.,Infect. Immunol.(1994) 62:1669-1676.
Ulrich et al.,Adv. Virus Res.vol. 50 (1998) Academic Press pp. 141-182.
Qari et al.,Lancet(1993) 341(8848):780-783.
Moreno et al.,J. Immunol.(1993) 151(1): 489-499.
Hoffman et al.,Malaria Vaccine Development,Chapter 3: Attacking the Infected Hepatocyte, 1996 American Society for Microbiology, Washington, D.C.
Calvo-Calle et al.,J. Immunol.(1997) 159(3): p. 1362-1373.
Coatney et al. (1962) 9:290-293.
Krüger et al.,Biol. Chem.(1999) 380:275-276.
Nardin et al.,J. Exp. Med.(1982) 156:20-30.
Poster presented by J. Haron at the Center for Advanced Technology and Medicine (CABM) Symposium, Rutgers University Medical Center on Oct. 13-14, 1999.
Isaguliants et al.,Immunol. Ltr.(1994) 42:173-178.
Schodel et al.,J. Biotechnol.(1996) 44:91-96.
Wynne et al.,Mol. Cell(Jun. 1999) 3:771-780.
Carl R. Noller.,Chemistry of Organic Compounds.35-, 1952.
Lyons et al..,J. Infection and Immunity,70(12):6860-6870(Dec. 2002).
Sällberg et al.,Invervirology,45:350-361 (2002).
Palenzuela et al.,Biotecnologia Aplicada,vol. 18(3):137-142 (2002.
Milich et al.,Vaccine,20:771-788 (2002).
Lazdina et al.,Journal of General Virology,84:139-146 (2003).

Affiliated with

Also associated with

Rating

Malaria immunogen and vaccine does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Malaria immunogen and vaccine, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Malaria immunogen and vaccine will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3426449