Malaria associated antigen and preparing process thereof

Details Malaria associated antigen and preparing process thereof Malaria associated antigen and preparing process thereof

1984-06-07

1987-02-17

Kight, John

Drug, bio-affecting and body treating compositions

Lymphokine

424 93, 424107, 530380, 530395, 530806, 514 2, 514 8, 514895, A61K 3900, C07K 1514

Patent

active

046438963

ABSTRACT:
Disclosed is a novel malaria associated antigen (CRA) and a preparing process of the antigen.
CRA according to the invention can be obtained from Plasmodium-infected erythrocytes by firstly homogenizing Plasmodium-infected erythrocytes, dissolving the thus obtained precipitate by means of a solubilizing agent, and being followed by isolating glycoprotein which can be bound to lectin which can enter into specific combination with terminal mannose, from the supernatant component of the solution.
Thus obtained CRA is very useful and effective as a malaria vaccine.

REFERENCES:
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patent: 4416872 (1983-11-01), Alving et al.
patent: 4466917 (1984-08-01), Nussevzueig et al.
Lectins, ed. T. C. Bag Hansen, "Lectin Binding by Malaria-Infected Erythrocyte", Adehiyi, 1982.
CA No. 5797v, vol. 93, 1980, Plasmodium Lophurae: Lectin . . . Membranes, Takahashi et al.
Takahashi et al., Plasmodium Iopnurae: Lectin-Mediated Agglutination of Infected Red Cells and Cytochemical Fine-Structure Detection . . . Experimental Parasitology 49, 233-247 (1980).
Kilejian, Stage-Specific Proteins and Glycoproteins of Plasmodium Falciparum: Identification of Antigens Unique . . . Proc. Natl. Acad. Scie., USA, 77, No. 6, pp. 3695-3699, Jun. 1980.
Wilson et al., Antigens Associated with Plasmodium Falciparum Infections in Man, The Lancet, Jul. 26, 1969.
Mack et al., in vitro Cultivation and Partial Purification of Plasmodium Falciparum Antigen Suitable for Vaccination Studies in Aotus Monkeys, The Journal of Parasitology, vol. 64, No. 1, Feb. (1978).
Grothaus and Kreier, Isolation of Soluble Component of Plasmodium Berghei Which Induces Immunity in Rats, Infection and Immunity, pp. 245-253, (1980).

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