Making dosage units using low shear granulation

Details Making dosage units using low shear granulation Making dosage units using low shear granulation

1999-03-12

2000-04-25

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424470, 424461, 424469, 424458, A61K 914

Patent

active

060541458

ABSTRACT:
Disclosed is a process for the preparation of pharmaceutical dosage units containing as an active substance of from 0.005 to 1.0% by weight of micronised Org 30659, comprising (a) a mixing step comprising bringing into association the active substance and a suitable carrier to form a mixture, and (b) a granulating step in which the mixture is granulated to form agglomerates or granules by wetting the mixture with a binder liquid, the wetting being conducted under agitation, characterised in that the granulation step (b) is conducted so as to exert on the granules a shear force which does not exceed the tensile strength of the agglomerates or granules. The process leads to granules and tablets having an excellent content/uniformity.

REFERENCES:
patent: 4914089 (1990-04-01), Tax
patent: 5098714 (1992-03-01), Wright et al.
patent: 5508042 (1996-04-01), Oshlack et al.

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