Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Synthesis of peptides
Reexamination Certificate
2006-12-12
2006-12-12
Li, Baoqun (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Synthesis of peptides
C424S093100, C424S225100, C435S007100
Reexamination Certificate
active
07148323
ABSTRACT:
The invention describes the identification of a major neutralization site of hepatitis E virus (HEV) and the use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to HEV. The invention also describes the isolation and characterization of neutralizing chimpanzee monoclonal antibodies reactive to the neutralization site and the use of these antibodies in the diagnosis, treatment and prevention of HEV.
REFERENCES:
patent: WO 94/06913 (1994-03-01), None
patent: WO 95/21858 (1995-08-01), None
Junken, H. et al. DNA inoculation with a plasmid vector carrying the hepatitis E virus structural protein gene induces immune response in mice.Vaccine.1997. 15(4):357-362.
Schofield, D.J. et al. Characterization of 17 Chimpanzee Monoclonal Antibodies (MABS) to Hepatitis E Virus (HEV) Open Reading Frame 2 (CAPSID) Protein Generated Using Phage Display, Epitope Masking, and Repertoire Cloning.American Journal Of Tropical Medicine And Hygene.1999. 61(3):Suppl. ABSTRACT.
Schofield, D.J. et al. Identification By Phage Display And Characterization Of Two Neutralizing Chimpanzee Monoclonal Antibodies To The Hepatitis E Virus Capsid Protein.Journal Of Virology.2000. 74(12):5548-5555.
Emerson Suzanne U.
Purcell Robert H.
Schofield Darren
Knobbe Martens Olson & Bear LLP
Li Baoqun
The United States of America as represented by the Department of
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