Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Blood proteins or globulins – e.g. – proteoglycans – platelet...
Reexamination Certificate
2005-08-16
2005-08-16
Housel, James (Department: 1648)
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Blood proteins or globulins, e.g., proteoglycans, platelet...
C424S141100, C424S130100, C424S134100, C424S147100, C424S149100, C424S093100
Reexamination Certificate
active
06930176
ABSTRACT:
The invention describes the identification of major neutralization site of hepatitis E virus (HEV) and the use of this neutralization site in methods of vaccination and in methods of screening for neutralizing antibodies to HEV. The invention also describes the isolation and characterization of neutralizing chimpanzee monoclonal antibodies reactive to the neutralization site and the use of these antibodies in the diagnosis, treatment and prevention of HEV.
REFERENCES:
patent: 94/06913 (1994-03-01), None
patent: 95/21858 (1995-08-01), None
H. Junken et al.DNA inoculation with a plasmid vector carrying the hepatitis E virus structural protein gene induces immune response in mice.VACCINE, 1997, vol. 15, No. 4, pp. 357-362.
D. J. Schofield et al.Characterization of 17 Chimpanzee Monoclonal Antibodies(MABS)To Hepatitis E Virus(HEV)Open Reading Frame 2(CAPSID)Protein Generated Using Phage Display, Epitope Masking And Repertoire Cloning.American Journal of Tropical Medicine and Hygiene, 1999, vol. 61, No. 3, Suppl., ABSTRACT.
D. J. Schofield et al.Identification By Phage Display and Characterization of Two Neutralizing Chimpanzee Monoclonal Antibodies to the Hepatitis E Virus Caspid Protein.Journal of Virology Jun. 2000, vol. 74, No. 12, pp. 5548-5555.
Emerson Suzanne U.
Purcell Robert H.
Schofield Darren
Housel James
Knobbe Martens Olson & Bear LLP
Li Bao Qun
The United States of America as represented by the Secretary of
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