Magnetoresistance-based method and apparatus for molecular detec

Details Magnetoresistance-based method and apparatus for molecular detec Magnetoresistance-based method and apparatus for molecular detec

1996-05-31

2000-05-02

Chin, Christopher L.

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

324252, 360113, 422 8202, 436149, 436151, 436806, G01N 33553

Patent

active

060571675

ABSTRACT:
A binding of a molecule with a molecular receptor at a binding site is sensed using a magnetoresistive member proximate to the binding site. A magnetic field associated with the molecule acts to modify an electrical characteristic of the magnetoresistive member when the molecule binds with the molecular receptor. The magnetic field is produced by a magnetic member, such as a magnetic bead, attached to the molecule. Preferably, the magnetoresistive member is integrated with a substrate which supports the binding site. A readout device, such as a thin-film transistor, can also be integrated on the substrate to provide a signal indicative of a binding event.

REFERENCES:
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patent: 4835509 (1989-05-01), Yoshino et al.
patent: 5006906 (1991-04-01), Deri
patent: 5074977 (1991-12-01), Cheung et al.
patent: 5466348 (1995-11-01), Holm-Kennedy
patent: 5502325 (1996-03-01), Sokolich et al.

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