Magnetocentrifugation

Details Magnetocentrifugation Magnetocentrifugation

1995-04-18

1996-10-15

Savage, Matthew O.

Liquid purification or separation

Processes

Using magnetic force

4351739, B01D 3506

Patent

active

055651054

ABSTRACT:
A device and method for performing particle separation. Separation and purification of biological macromolecules are important steps in basic molecular biology research and biotechnology product development. Throughout the years researchers have worked on developing different and better techniques. The present invention is directed to a new technique for separation of charged particles by applying a magnetic field parallel to the axis of rotation during centrifugation. Magnetocentrifugation performed according to the present invention thus enhances the separation of charged particles under centrifugation by adding a magnetically induced force, namely a Lorentz force, in addition to centrifugal, buoyant, and frictional forces. The technique of magnetocentrifugation may be utilized for separating particles with similar densities but different charges, and may be used for free as well as immobilized charged macromolecules such as proteins and DNA.

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patent: 3757846 (1973-09-01), Herman
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patent: 4804355 (1989-02-01), Brimhall et al.
patent: 5039312 (1991-08-01), Hollis et al.
patent: 5173262 (1992-12-01), Burtis et al.
Roberto Rodriquez, Magnetocentrifugation, Masters of Science in Engineering Thesis--submitted to the Johns Hopkins University, Oct., 1992.

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