Magneto-optic biosensor using bio-functionalized magnetized...

Details Magneto-optic biosensor using bio-functionalized magnetized... Magneto-optic biosensor using bio-functionalized magnetized...

2007-10-19

2009-12-29

Toatley, Jr., Gregory J (Department: 2877)

Optics: measuring and testing

By particle light scattering

With photocell detection

C356S337000

Reexamination Certificate

active

07639359

ABSTRACT:
A biosensor utilizing bio-functionalized magnetic nanoparticles is provided. An external magnetic field is applied to a suspension of magnetic nanoparticles. A linearly polarized incident light is applied to the suspension of magnetic nanoparticles. A photocurrent from polarized light scattering by bio-functionalized magnetic nanoparticles in liquid is detected. The magneto-optic sensing technique is applied to a micro-fluidic channel for rapid and sensitive detection with a small sample amount, and subsequent magnetic separation for detoxification. This technique is used for the detection of Brownian relaxation with time sweep as well as frequency sweep. The magneto-optical sensor enables rapidly detecting changes in local dynamic properties of the magnetic nanoparticles in liquids and magnetic modulation of ferromagnetic particles in liquid provides increased signal sensitivity.

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Magneto-optic measurement of Brownian relaxation of magnetic nanoparticles, S.H. Chung et al., J. Magnetism Magnetic Materials, 2007, doi:10.1016/j.jmmm.2007.05.016.

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