Magnetically-localizable, polymerized lipid vesicles and method

Details Magnetically-localizable, polymerized lipid vesicles and method Magnetically-localizable, polymerized lipid vesicles and method

1985-03-21

1987-03-24

Yasko, John D.

Surgery

Means for introducing or removing material from body for...

Treating material introduced into or removed from body...

128 13, A61M 3100

Patent

active

046522573

ABSTRACT:
Polymerizable lipids are used to encapsulate therapeutic agents and ferronetic particles into lipid vesicles. The vesicles are polymerized, injected into the body upstream of a targeted capillary bed, allowed to flow within the bloodstream to the targeted site, and held there by an externally applied magnetic field. The magnetic field is oscillated at sufficient periodicity to destabilize or disrupt the vesicle membrane thus effecting a controlled release of the therapeutic agent.

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patent: 4331654 (1982-05-01), Morris
patent: 4345588 (1982-08-01), Widder et al.
patent: 4590922 (1986-05-01), Gordon

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