Magnetic separation of magnetized particles from biological flui

Details Magnetic separation of magnetized particles from biological flui Magnetic separation of magnetized particles from biological flui

1987-12-10

1990-03-20

Naff, David M.

Chemistry: molecular biology and microbiology

Miscellaneous

209213, 210222, 435 2, 435173, 435239, 4352401, 435261, 435284, 435286, 435287, 435316, 435803, 436526, 436824, C12N 1300, C12N 500, C12M 300, B03C 100

Patent

active

049101480

ABSTRACT:
A method and device are provided for separating magnetized particles from biological fluids. Cells such as cancer cells coated with magnetized particles can be separated from uncoated healthy cells. A fluid mixture of cancer cells, healthy cells and magnetizable particles is introduced into a container such as a disposable blood bag which is attached in a cassette on an underlying plane magnetic plane that provides a magnetic field. Incubation is carried out during which the cancer cells become coated with the magnetizable particles. The magnetic field pulls the coated cells down towards the bottom of the bag and anchors them, and uncoated healthy cells are removed from the bag. The separated uncoated healthy cells may be advanced through a final separation unit where any loose magnetizable particles are removed. There is provided means for adjusting vertical distance between the cassette and the magnetic plane and for agitating fluid within the container attached to the cassette. A magnetic screen plate may be placed between the cassette and the magnetic plate to short circuit the magnetic field during incubation. The screen plate is removed to carry out separation.

REFERENCES:
patent: 4624923 (1986-11-01), Margel
patent: 4710472 (1987-12-01), Saur et al.
patent: 4752563 (1988-06-01), Kortright

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