Magnetic separation apparatus and methods

Liquid purification or separation – With alarm – indicator – register – recorder – signal or... – Transparent

Reexamination Certificate

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C210S222000, C209S223100, C436S177000, C436S526000, C204S660000

Reexamination Certificate

active

06890426

ABSTRACT:
Apparatuses and methods for separating, immobilizing, and quantifying biological substances from within a fluid medium. Biological substances are observed by employing a vessel (6) having a chamber therein, the vessel comprising a transparent collection wall (5). A high internal gradient magnetic capture structure may be on the transparent collection wall (5), magnets (3) create an externally-applied force for transporting magnetically responsive material toward the transparent collection wall (5). The magnetic capture structure comprises a plurality of ferromagnetic members and has a uniform or non-uniform spacing between adjacent members. There may be electrical conductor means supported on the transparent collection wall (5) for enabling electrical manipulation of the biological substances. The chamber has one compartment or a plurality of compartments with differing heights. The chamber may include a porous wall. The invention is also useful in conducting quantitative analysis and sample preparation in conjunction with automated cell enumeration techniques.

REFERENCES:
patent: 4729949 (1988-03-01), Weinreb
patent: 4735504 (1988-04-01), Tycko
patent: 4989978 (1991-02-01), Groner
patent: 5030560 (1991-07-01), Sinor
patent: 5053344 (1991-10-01), Zborowski
patent: 5089128 (1992-02-01), Garaschenko
patent: 5200084 (1993-04-01), Liberti
patent: 5340749 (1994-08-01), Fujiwara
patent: 5375606 (1994-12-01), Slezak
patent: 5411863 (1995-05-01), Miltenyi
patent: 5428451 (1995-06-01), Lea
patent: 5451525 (1995-09-01), Shenkin
patent: 5466574 (1995-11-01), Liberti
patent: 5494831 (1996-02-01), Kindler
patent: 5498550 (1996-03-01), Fujiwara
patent: 5541072 (1996-07-01), Wang
patent: 5985153 (1999-11-01), Dolan
patent: 6013532 (2000-01-01), Liberti et al.
patent: 6136182 (2000-10-01), Dolan
patent: WO 9411078 (1994-05-01), None
patent: WO 9626782 (1996-09-01), None
Chen et al., “Automated Enumeration of CD34+ Cells in Peripheral Blood and Bone Marrow”, J. of Hematotherapy; 3:3-13 (1994).
deGroth et al., “The Cytodisk: A Cytometer Based Upon a New Principle of Cell Alignment”, Cytometry; 6:226-233 (1995).
Kamentsky et al., “Microscope-Based Multiparameter Laser Scanning Cytometer Yielding Data Comparable to Flow Cytometry Data”, Cytometry; 12:381-387 (1991).
Stewart, et al., “Quantitation of Cell Concentration Using the Flow Cytometer”, Cytometry; 2:238-243 (1982).
Takayasu et al., “HGMS Studies of Blood Cell Behavior in Plasma”, IEEE Transactions of Magnetics, 18:1520-1522 (1982).
Takayasu et al., “High Gradient Magnetic Separation II. Single Wire Studies of Shale Oils”, IEEE Transactions on Magnetics; 18:1695-1697 (1982).
Zwerner et al., “A Whole Blood Alternative to Traditional Methods for CD4+ T Lymphocyte Determine” J. of Acquired Immune Deficiency Syndromes and Human Retrovirology; 14:31-34 (1997).
Ahn, et al., “A Fully Integrated Micromachined Magnetic Particle Manipulator and Separator”, Proc. Workshop on Micro Electro Mechanical System IEEE, ISBN: 0-7803-1834-X, Jan. 25-28, 1994, pp. 91-96.

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