Magnetic separation apparatus and method

Details Magnetic separation apparatus and method Magnetic separation apparatus and method

1995-06-07

1997-11-25

Saunders, David

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

210695, 210805, 435 2, 435 6, 435 71, 435 30, 435325, 435372, 436806, C12N 100, C12Q 168, G01N 33543

Patent

active

056912080

ABSTRACT:
Improved magnetic separators, devices and methods for magnetic separation procedures are provided. The improved separation devices contain matrices which provide uniform pores or channels that reduce the entrapment of air or non-target substances, and decrease the loss of target substances due to mechanical disruption. Target cells, from various systems and organs, or other target biological substances are labeled in conjunction with a suitable specific binding member, and isolated using the devices and methods of the present invention. In its simplest form, the cell separation system of the present invention has two main components: a magnetic separator and a cell separation reagent. A more complex separation device includes fluid passages, collection and storage containers and the separation column. The fluid circuitry can be constructed with integrated valves, or the valves may be applied externally to the fluid pathways.

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