Magnetic separation apparatus

Liquid purification or separation – Magnetic

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210456, B01D 3506

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active

057954704

ABSTRACT:
A magnetic separation apparatus is disclosed herein. The apparatus includes a flow-through vessel defining a plenum and an inlet port for introducing fluid into the plenum. A hydrodynamic damping structure is provided between the inlet port and plenum for reducing turbulence in the fluid. A mounting device is provided with a slot therein for supporting and receiving the vessel. The mounting device also supports a first array of magnets along one side of the slot and arranged adjacent one another to face the slot with alternating polarity, and a second array of magnets along the opposite side of the slot from the first array arranged adjacent one another to face the slot with alternating polarity and confronting and magnetically opposing the magnets in the first array. The first and second arrays of magnets produce a magnetic field within the plenum having a field strength that is maximum at a location at the interior surface of a wall of the vessel and that is minimum at a geometrical center of the plenum so that magnetic particles in the fluid are attracted to and immobilized on the inner surface of the vessel.

REFERENCES:
patent: 564858 (1896-07-01), Whitacre et al.
patent: 3326374 (1967-06-01), Jones
patent: 3402820 (1968-09-01), Lohmann
patent: 3567026 (1971-03-01), Kolm
patent: 3608718 (1971-09-01), Aubrey et al.
patent: 3676337 (1972-07-01), Kolm
patent: 3902994 (1975-09-01), Maxwell et al.
patent: 3970518 (1976-07-01), Giaever
patent: 3987649 (1976-10-01), Eddelman
patent: 4018886 (1977-04-01), Giaever
patent: 4141687 (1979-02-01), Forrest et al.
patent: 4209394 (1980-06-01), Kelland
patent: 4230685 (1980-10-01), Senyei et al.
patent: 4265746 (1981-05-01), Zimmerman, Sr. et al.
patent: 4265755 (1981-05-01), Zimmerman
patent: 4267234 (1981-05-01), Rembaum
patent: 4452773 (1984-06-01), Molday
patent: 4498987 (1985-02-01), Inaba
patent: 4510244 (1985-04-01), Parks et al.
patent: 4554088 (1985-11-01), Whitehead et al.
patent: 4659678 (1987-04-01), Forrest et al.
patent: 4663029 (1987-05-01), Kelland et al.
patent: 4672040 (1987-06-01), Josephson
patent: 4714680 (1987-12-01), Civin
patent: 4795698 (1989-01-01), Owen et al.
patent: 4895650 (1990-01-01), Wang
patent: 4904391 (1990-02-01), Freeman
patent: 4910148 (1990-03-01), Sorensen
patent: 4935147 (1990-06-01), Ullman et al.
patent: 4946590 (1990-08-01), Hertzog
patent: 4988618 (1991-01-01), Li et al.
patent: 5055190 (1991-10-01), Hayes et al.
patent: 5061620 (1991-10-01), Tsukamoto et al.
patent: 5070852 (1991-12-01), Po et al.
patent: 5108933 (1992-04-01), Liberti et al.
patent: 5129382 (1992-07-01), Stamps, Sr. et al.
patent: 5186827 (1993-02-01), Liberti et al.
patent: 5200084 (1993-04-01), Liberti et al.
patent: 5466574 (1995-11-01), Liberti et al.
patent: 5584994 (1996-12-01), Hattori et al.
Forrest et al., "Magnetic Particle Radioimmunoassay" in Immunoassays for Clinical Chemistry, pp. 147-162, Hunter et al. eds Churchill Livingston (1983).
The Properties of Magnetic Supports in Relation to Immobilized Enzyme Reactors, Robinson et al., Biotechnology and Bioengineering, vol. XV (1973).
The Dynal MPC-1 (manufactured by DYNAL, Inc., Great Neck, NY) product information sheet (1987).
BioMag Separator (manufactured by Advanced Magnetics, Inc., Cambridge MA) catalog pages (3 sheets).
Magnetic Separator (manufactured by Ciba-Corning Medical Diagnostics, Wampole, MA) catalog cover and catalog pages (2 sheets).
Magnetic Separator (Made by Milteny Biotech. GmbH, Gladbach, Germany) Product information sheet.
High Gradient Magnetic Separation Therory and Applications, R.R. Oder, IEEE Transactions on Magnetics, vol. MAG-12, No. 5, pp. 428-435, Sep., 1976.
Magnetite-Protein Conjugates for the Separation of Cells by High Gradient Magnetic Filtration, C.S. Owen et al., Cell Separation Methods and Selected Applications, vol. 4, 1987.
Magnetic Separation Techniques: Their Application to Medicine, J.T. Kemshead et al., Molecular and Cellular Biochemistry 67: 11-18 (1985).
Magnetic Solid-Phase Radioimmunoassay, L.S. Hersh et al., Clinica Chimica Acta 63:69-72 (1975).
Ivan Damjanov, "Biology of Disease: Lectin Cytochemistry and Histochemistry", Lab. Invest. 57:5-20 (1987).
Magnetic Separator System (manufactured by Serono Diagnostics, Norwell, MA) catalog pages (2 sheets).
Hancock, J.P. et al., "A rapid and highly selective approach to cell separations using an immunomagnetic colloid", J. of Immunol. Meth. 164:51-60 (1993).
Liberti P.A. et al., "Ferrofluid as a matrix for magnetic separations", 1st John Ugelstad Conf., pp. 47-61, (1991).
Areman, E.M., et al., Bone Marrow and Stem Cell Processing: A Manual of Current Techniques, pp. 267-285, (1992).
Bieva, C.J. et al., "Malignant Leukemic cell separation by iron colloid immunomagnetic adsorption", Exp. Hematol. 17:914-920, (1988).
Powers, F.J., et al., Separation of small-cell lung cancer cells from bone marrow using immunomagnetic beads, in Bone Marrow Processing and Purging, A.P. Gee ed., pp. 257-267.
Rhodes, E.G.H. et al., "Peanut Agglutinin purging and magnetic microspheres" in Advances in Bone Marrow Purging, pp. 139-146, (1992).
Okarma, T. et al., The AIS collector: a new technology for stem cell purification, Advances in Bone Marrow Purging and Processing, pp. 487-504, (1992).
Reading, C.L. et al., "Magnetic affinity colloid elimination of specific cell populations from bone marrow", in Bone Marrow Transplantation: Proceedings of the 3rd International Symposium: Autologous Bone Marrow Transplantation, Dec. 4-5, 1986, pp. 133-142.
Molday, R.S. et al., "Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cell." J. Immunol. Meth. 52:353-367 (1982).
Straus, L.C. et al., "Selection of normal hematopoietic stem cells for bone marrow transplantation using immunomagnetic microspheres and CD34 antibody." Am. J. Ped. Hematology/Oncology 13:217-221.
Trickett, A.E., et al., "Comparison of magnetic particles for immunomagnetic bone marrow purging using an acute lymphoblastic leukemia model". Transplantation Procedings 22:2177-2178.
Padanabhan, R., et al., "Purification of transiently transfected cells by magnetic-affinity cell sorting". J. of Immunomagnetics 16:91-102 (1989).
Brun, A., et al., "A new method for isolation of reticulocytes: positive selection of human reticulocytes by immunomagnetic separation" Blood 76:2397-2403 (1990).
Ganshirt-Ahlert, D., et al., "Detection of Fetal Trisomies 21 and 18 from maternal blood using triple gradient and magnetic cell sorting". Am. J. Immunol. 30:194-201 (1993).
Muir, P., et al., "Rapid diagnosis of enterovirus infection by magnetic bead extraction and polymerase chain reaction detection of enterovirus RNA in clinical specimens". J. Clin. Micro. Jan. 1993 pp. 31-38.

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