Electricity: measuring and testing – Particle precession resonance – Using a nuclear resonance spectrometer system
Patent
1992-01-03
1993-08-10
Tokar, Michael J.
Electricity: measuring and testing
Particle precession resonance
Using a nuclear resonance spectrometer system
324307, G01R 3320
Patent
active
052352781
ABSTRACT:
A plurality of sequences act on an examination zone in the presence of a uniform, steady magnetic field, each of the sequences comprising at least three RF pulses which are preferably formed as 90.degree. pulses, applying between the second and the third RF pulse and after the third RF pulse magnetic gradient fields (G.sub.x) having an amplitude and a duration such that spin resonance signals occurring after the third RF pulse are determined exclusively by double quantum coherence. Thus, spatial and spectral determination of a lactate component is simultaneously possible when it is ensured that at least one magnetic gradient field is applied between or after the three RF pulses and when the time integral over at least one of these gradient fields is varied during repetition of the sequences, the second RF pulse (HF.sub.2) being frequency selective to reduce the lipid component (L.sub.1) near the lactate component (M.sub.1) so that the nuclear magnetization of the component (M.sub.2) coupled to the lactate component (M.sub.1) is excited, but not the nuclear magnetization of the component (L.sub.2) coupled to the lipid component (L.sub.1).
REFERENCES:
patent: 5077524 (1991-12-01), Hurd et al.
patent: 5111143 (1992-05-01), McKinnon et al.
A. Bax et al., "Separation of the Different Orders of NMR Multiple-Quantum Transitions by the Use of Pulsed Field Gradients", Chemical Physics Letters, vol. 69, No. 3, Feb. 1, 1990, pp. 567-570.
D. M. Freeman et al., "Monitoring Steady State Tumor Lactic Acid Levels In Vivo in Different Tumor Cell Lines Using Two-Dimensional Double Quantum Coherence Transfer Spectroscopy", SMRM Abstracts, San Francisco, (1988), pp. 212.
Bosiger Peter
McKinnon Graeme
Slobod Jack D.
Tokar Michael J.
U.S. Philips Corp.
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