Magnetic resonance (MR) image enhancement compounds for specific

Details Magnetic resonance (MR) image enhancement compounds for specific Magnetic resonance (MR) image enhancement compounds for specific

1984-12-10

1987-04-07

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

128653, 128654, 436173, 436803, 436806, 540512, 540514, A61K 4900, A61B 505, A61B 600

Patent

active

046560262

ABSTRACT:
An improved imaging technique involving nuclear magnetic resonance. Known drug or neurotransmitter receptor ligands are covalently bound to magnetic resonance image enhancing spin label compounds, such as sterically hindered free radical nitroxide compounds, with the resulting adduct being administered to a patient, and thereafter when the ligand is bound to specific receptor sites in the soft tissue such as the brain, regional tissue area is assessed with nuclear magnetic resonance, allowing diagnostic discrimination.

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Keana, J. F., Chemical Reviews, vol. 78, (1978), pp. 37-64.
Brasch, Robert C., "Work in Progress: Nuclear Magnetic Resonance Study of a Paramagnetic Nitroxide Contrast Agent for Enhancement of Renal Structures in Experimental Animals", Radiology 147, 773 (1983).
Brasch, Robert C., "Brain Nuclear Magnetic Resonance Imaging Enhanced by a Paramagnetic Nitroxide Contrast Agent: Preliminary Report" AJR 141, 1019 (1983).
Brasch, Robert C., "Nuclear Magnetic Resonance Session" Investigative Radiology Jul.-Aug., 1984 (S148).

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