MAGNETIC RESONANCE METHOD FOR ASSESING AMIDE PROTON TRANSFER...

Chemistry: analytical and immunological testing – Nuclear magnetic resonance – electron spin resonance or other...

Reexamination Certificate

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C600S410000, C600S416000, C600S456000

Reexamination Certificate

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06943033

ABSTRACT:
Featured is an MRI/NMR methodology or process to detect amide protons of endogenous mobile proteins and peptides via the water signal. Such methods and processes can be used for the purposes of detection of pH effects and labile amide proton content of mobile proteins/peptides or content changes thereto using MRI Also featured are methods whereby assessment of determined pH effects and amide proton content or content changes and related mobile protein and/or peptide content or content changes can be used in connection with diagnosis, program and treatment of brain related disorders and diseases, cardiac disorders and diseases, and cancer and to use such methods for monitoring, detecting and assessing protein and peptide content in vivo and pathologically for any of a number of diseases or disorders of a human body, including but not limited to cancers, ischemia, Alzheimers and Parkinsons.

REFERENCES:
Guivel-Scharen et al. “Detection of Proton Chemical Exchange Between Metabolites and Water in Biological Tissues”, J. Magn. Reson., 1998, v. 133, pp. 36-45.
Moon et al. “Determination of Intracellualr pH by 31P Magnetic Resonance”, J. Biol. Chem., 1973, v. 248, No. 20, pp. 7276-727.
Kato, et al., “Alterations in brain phosphorous metabolism in Bi polar disorder detected by in vivo31P and7Li magnetic resonance spectroscopy”, J. Affect Disorder Jan. 1993; 27(1):53-9.
Mori, et al., “Proton NMR spectroscopy of solvent-saturable resonances: a new approach to study pH effects in situ”, Magnetic Resonance in Medicine (1998), 40(1), 36-42.
Ward, et al., “Determination of pH Using Water Protons and Chemical Exchange Dependent Saturation Transfer (CEST)”, Magnetic Resonance in Medicine 44:799-802 (2000).
Goffeney, et al., “Sensitive NMR Detection of Cationic-Polymer-Based Gene Delivery Systems Using Saturation Transfer via Proton Exchange”, J. Am. Chem. Soc. 2001, 123, 8628-8629.

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