Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1993-03-26
1994-11-08
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
436173, 436806, 1286534, 128654, 514 12, 514 54, 514 57, 514 59, A61B 5055, A61K 31715
Patent
active
053624785
ABSTRACT:
In accordance with the present invention, compositions comprising fluorine-containing magnetic resonance imaging agent(s) contained within polymeric shells are provided. Invention compositions are useful, for example, as contrast agents for magnetic resonance imaging (MRI). Fluorinated compounds in general are hydrophobic and as such have limited water solubility; thus the invention method permits preparation of such compounds in a biocompatible form suitable for ready delivery. The shell diameter is typically approximately 2 microns in diameter. Consequently, these materials have organ specificity due to rapid scavenging by the reticuloendothial system (RES) or the mononuclear phagocyte (MNP) system upon intravenous injection. Furthermore, fluorocarbon filled polymeric shells of the invention can be used to measure and monitor local oxygen and temperature.
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Manning et al., "A Preliminary Report Comparing Magnetic Resonance Coronary Angiography with Conventional Angiography," The New England Journal of Medicine 328:828-832 (1993).
Desai Neil P.
Grinstaff Mark W.
Sandford Paul A.
Soon-Shiong Patrick
Suslick Kenneth S.
Hollinden Gary E.
Vivorx Pharmaceuticals, Inc.
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