Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Patent
1996-06-17
1998-07-28
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
424 937, 534 7, A61B 5055
Patent
active
057859531
ABSTRACT:
A method of imaging a spatial distribution of a noble gas by nuclear magnetic resonance spectrometry includes detecting a spatial distribution of at least one noble gas by NMR spectrometry and generating a representation of said spatial distribution of the noble gas. The noble gas is selected from noble gas isotopes having nuclear spin, preferably Xenon-129 and/or Helium-3. The noble gas is at least thermally or equilibrium polarized and is preferably hyperpolarized, most preferably hyperpolarized by optical (laser) pumping in the presence of an alkali metal or by metastability exchange. The generation of the representation of the noble gas spatial distribution includes at least one dimension, preferably 2 or 3 dimensions of the spatial distribution. The noble gas may be imaged according to the invention in chemical or biological systems, preferably in a human or animal subject or organ system or tissue thereof. Also, apparatus for nuclear magnetic resonance imaging of the spatial distribution of at least one noble gas includes means for imaging a noble gas by NMR spectrometry and means for providing and/or storing imageable quantities of a noble gas, preferably hyperpolarized Xenon-129 and/or Helium-3. Also, a medical composition includes a medically acceptable bifunctional gas effective for in vivo anesthesiological and NMR imaging functions, including at least one noble gas, preferably hyperpolarized Xenon-129 and/or Helium-3.
REFERENCES:
patent: 4586511 (1986-05-01), Clark, Jr.
patent: 4775522 (1988-10-01), Clark, Jr.
patent: 4793357 (1988-12-01), Lindstrom
patent: 4862359 (1989-08-01), Trivedi et al.
patent: 4996041 (1991-02-01), Arai et al.
patent: 5357959 (1994-10-01), Fishman
patent: 5545396 (1996-08-01), Albert et al.
Albert et al. Chem. Abstracts 121:128933r(1994)from: Nature 370(6486):199-201 (1994).
Pfeffer, M Chem. Abstracts 121:174319 (1994).
Albert, MS et al., Abs. 11th Ann. Mtg. Soc. Magnetic Resonance Medicine, 2104, 4710(1992).
Bhaskar, ND et al., Phys. Rev. Lett. 49:25 (1982).
Raftery, D et al., Chem. Phys. Let., 191:385 (1992).
Miller, KW et al., Proc. Natl. Acad. Sci. 78:4946 (1981).
Wyrwicz, A.M., Schofield, J.C., Tillman, P.C., Gordon, R.E., and Martin, P.A., Science, 222:428 (1983).
Evers, A.S., Berkowitz, B.A., and d'Avignon, D.A., Nature, 328:157 (1987).
Wyrwicz, A.M., Li, Y.-E., and Schofield, J.C., FEBS Lett., 162:334 (1983).
Burt, C.T., Moore, R.R., Roberts, M.F., and Brady, T.J., Biochim. Biophys. Acta., 805:375 (1984).
Burt, C.T., Moore, R.R., and Roberts, M.F., J. Magn. Reson., 53:163 (1983).
Lockhart, S.H., Cohen, Y., Yasuda, N., Kim, F., Litt, L., Eger, E.I., Chang, L.-H., and James, T., Anesthesiology, 73:455 (1990).
Mason, J., in Multinuclear NMR, Mason, J., ed., pp. 606-607, Plenum Press, New York (1987).
Barany, M., Spigos, D.G., Mok, E., Venkatasubramanian, P.N., Wilbur, A.C., and Langer, B.G., Magn. Reson. Imaging, 5:393 (1987).
Fullerton, G.D., and Cameron, I.L., Chapter 3 in Biomedical Magnetic Resonance Imaging: Principles, Methodology, and Applications, Wehrli, F.W., Shaw, D.S., and Kneeland, J.B., eds., pp. 115-155, VCH Publishers, New York (1988).
Susskind, H., Atkins, H.L., Klopper, J.K., Ansari, A.N., Richards, P., and Fairchild, R.G., Prog. Nucl. Med., 5:144 (1978).
Susskind, H., Ellis, K.J., Atkins, H.L., Cohn, S.H., and Richards, P., Prog. Nucl. Med., 5:13 1978).
Kendall, B.E., and Moseley, I.F., J. Neuroradiology, 8:3 (1981).
Imai, A., Meyer, J.S., Kobari, M., Ichijo, M., Shinohara, T., and Oravez, W.T., Neuroradiology, 30:463 (1988).
Yonas, H., Sekhar, L., Johnson, D.W., and Gur, D., Neurosurgery, 24:368 (1989).
Jameson, C.J., Jameson, A.K., and Hwang, J.K., J. Chem. Phys., 89:4074 (1988).
Carver, T.R., Science, 141:599 (1963).
Happer, W., Miron, E., Schaefer, S., Schreiber, D., van Wijngaarder, W.A., and Zeng, X., Phys. Rev. A, 29:3092 (1984).
Wagshul, M.E., and Chupp, T.E., Phys. Rev. A, 40:4447 (1989).
Wagshul, M.E., Thesis, Department of Physics, Harvard University (1991).
Grover, B.C., Phys. Rev. Lett., 40:391 (1978).
Schaefer, S.R., Cates, G.D., Chien, T.-R., Gonatas, D., Happer, W., and Walker, T.G., Phys. Rev. A, 39:5613 (1989).
Schaefer, S.R., Cates, G.D., and Happer, W., Phys. Rev. A, 41:6063 (1990).
Schearer, L.D., in Phys. Rev. Lett., 21:660 (1968).
Schearer, L.D., in Phys. Rev., 188:505 (1969).
Schearer, L.D., in Phys. Rev., 180:83 (1969).
Colegrove, F.D., Schearer, L.D., and Walters, G.K., Phys. Rev., 132:2561 (1963).
Hadeishi, T., and Liu, C.-H., Phys. Rev. Lett., 19:211 (1967).
Schearer, L.D., Phys. Lett., 28A:660 (1969).
Cates, G.D., Benton, D.R., Gatzke, M., Happer, W., Hasson, K.C., and Newbury, N.R., Phys. Rev. Lett., 65:2591 (1990).
Gatzke, M., Cates, G.D., Driehuys, B., Fox, D., Happer, W., and Saam, B., Phys. Rev. Lett., 70:690 (1993).
Cates, G.D., Fitzgerald, R.J., Barton, A.S., Bogorad, P., Gatzke, M., Newbury, N.R., and Saam, B., Phys. Rev. A, 45:4631 (1992).
Raftery, D., Long, H., Meersmann, T., Grandinetti, P.J., Reven, L., and Pines, A., Phys. Rev. Lett., 66:584 (1991).
Long, H.W. Gaede, H.C., Shore, J., Reven, L., Bowers, C.R., Kritzenberger, J., Pietrass, T., and Pines, A., J. Am. Chem. Soc., 115:8491 (1993).
Rinck et al., An Introduction to Magnetic Resonance in Medicine (1990).
Stark et al., eds., Magnetic Resonance Imaging, vol. 1, 2d ed. (1992) Chapters 1 and 2.
Hunt E.R., and Carr, H.Y., Phys. Rev., 130:2302 (1963).
Tilton, Jr., R.F., and Kuntz, Jr., I.D., Biochemistry, 21:6850 (1982).
Diehl, P., and Jokisaari, J., J. Magn. Reson., 88:669 (1990).
Cullen, S.C., and Gross, E.G., Science, 113:580 (1951).
Wilcock, R.J., Battino, R., Danforth, W.F., and Wilhelm, E., J. Chem. Thermodyn., 10:317 (1978).
Blumgart, H.L., and Weiss, S., J. Clin. Invest., 4:339-425 (1927).
Pollack, G.L., Himm, J.F., and Enyeart, J.J., J. Chem. Phys., 81:3239 (1984).
Wishnia, A., Biochemistry, 8:5064 (1969).
Bouchiat, M.A., Carver, T.R., and Varnum, C.M., Phys. Rev. Lett., 5:373 (1960).
Zeng, X., Wu, Z., Call, T., Miron, E., Schreiber, D., and Happer, W., Phys. Rev. A, 31:260 (1985).
Laloe, F., Nacher, P.J., Leduc, M., and Schearer, L.D., AIP Conf. Proc. #131 (Workshop on Polarized .sup.3 He Beams and Targets) (1984).
Ernst et al., Principles of Nuclear Magnetic Resonance in One and Two Dimensions (1987).
Wehrli, F.W., et al., eds., Biomedical Magnetic Resonance Imaging (1988).
Schoenborn, B.P., Nature, 208:760 (1965).
Moschos, A., and Reisse, J., J. Mag. Reson., 95:603 (1991).
Yonas, H., Laligam, S., Johnson, D.W., and Gur, D., Neurosurgery, 24:368 (1989).
Manabe, A., Miyazaki, T., and Toyoshima, H., Magn. Reson. in Med., 5:492-501 (1987).
Haase, A., Frahm, J., Matthaei, D., Hanicke, W., and Merboldt, K.D., J. Magn. Reson., 67:217 (1986).
Look, D.C., and Locker, D.R., Rev. Sci. Instrum., 41:250-251 (1970).
Norberg, R.E., in Rare Gas Solids, eds. Hohler, G., Springer-Verlag, New York (1984).
Yen, W.M., and Norberg, R.E., Phys. Rev., 131:269 (1963).
Kaplan, H.M., Brewer, N.R., and Blair, W.H., in The Mouse in Biomedical Research, eds. Foster, H.L., Small, J.D., and Fox, J.G., pp. 248-278, Academic Press, New York (1983).
Knudsen, G.M., Pettigrew, K.D., Patlak, C.S., and Paulson, O.B., Am. J. Physiol., In Press.
Kanal, E., and Wehrli, F.W., Chapter 2 in Biomedical Magnetic Imaging, Wehrli, F.W., Shaw, D., and Kneeland, J.B., eds., pp. 47-112, VCH Publishers, New York (1988).
Pollack, G.L., and Himm, J.F., J. Chem. Phys., 77:3221-3229 (1982).
Robillard, Jr., K.A., and Wishnia, A., Biochemistry, 11:3835-3840 (1972).
Albert Mitchell S.
Balamore Dilip
Cates, Jr. Gordon D.
Driehuys Bastiaan
Happer William
Hollinden Gary E.
The Research Foundation of State University of New York
The Trustees of Princeton University
LandOfFree
Magnetic resonance imaging using hyperpolarized noble gases does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Magnetic resonance imaging using hyperpolarized noble gases, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Magnetic resonance imaging using hyperpolarized noble gases will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-20827