Magnetic resonance imaging of liver and spleen with superparamag

Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent

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128653, 128654, 436173, 436526, 436806, A61K 4900, A61B 600

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active

048492108

ABSTRACT:
A method of imaging a tumor by magnetic resonance imaging (MRI) of liver and/or spleen is provided which employes microspheres composed of a biodegradeable matrix material with a particulate superparamagnetic contrast agent therein. The microspheres have diameters of less than 1.5 microns, and the ferromagnetic contrast agent, such as magnetite, has a particle size below 300 Angstroms. The superparamagnetic microspheres when administered intravenously segregate through the reticuloendothelial system in the liver and spleen where they reduce the T.sub.2 relaxation time to obtain improved MR imaging. In the T.sub.2 or mixed T.sub.1 and T.sub.2 images obtained by the MRI examination, the normal liver and spleen tissues appear dark and the tumor appears light with distinct margins therebetween.

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