Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Magnetic imaging agent
Patent
1987-08-11
1989-07-18
Warden, Robert J.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Magnetic imaging agent
128653, 128654, 436173, 436526, 436806, A61K 4900, A61B 600
Patent
active
048492108
ABSTRACT:
A method of imaging a tumor by magnetic resonance imaging (MRI) of liver and/or spleen is provided which employes microspheres composed of a biodegradeable matrix material with a particulate superparamagnetic contrast agent therein. The microspheres have diameters of less than 1.5 microns, and the ferromagnetic contrast agent, such as magnetite, has a particle size below 300 Angstroms. The superparamagnetic microspheres when administered intravenously segregate through the reticuloendothelial system in the liver and spleen where they reduce the T.sub.2 relaxation time to obtain improved MR imaging. In the T.sub.2 or mixed T.sub.1 and T.sub.2 images obtained by the MRI examination, the normal liver and spleen tissues appear dark and the tumor appears light with distinct margins therebetween.
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Molecular Biosystems, Inc.
Warden Robert J.
Wieder Stephen C.
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