Magnetic resonance imaging

Details Magnetic resonance imaging Magnetic resonance imaging

1996-02-23

1998-11-10

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

In vivo diagnosis or in vivo testing

Magnetic imaging agent

424 9363, 424 9364, 514836, 1286533, A61B 5055

Patent

active

058339477

ABSTRACT:
The invention provides a method of monitoring the vasodilatory or vasoconstrictive effects of a physiologically active substance administered to a human or non-human animal body, said method comprising the steps of: administering said substance into said body; administering into the systemic vasculature of said body a contrast enhancing amount of an intravascular paramagnetic metal containing magnetic resonance imaging contrast agent; subjecting said body to a magnetic resonance imaging procedure capable of generating from magnetic resonance signals from said body a series of temporally spaced images of at least a part of said body into which said agent passes, said procedure being a fast imaging procedure having an image acquisition time of less than five seconds; and detecting temporal variations in said signals or images whereby to monitor the vasoconstriction or vasodilation induced by said substance.

REFERENCES:
patent: 4639365 (1987-01-01), Sherry et al.
patent: 4647447 (1987-03-01), Gries et al.
patent: 4687658 (1987-08-01), Quay et al.
patent: 4687659 (1987-08-01), Quay et al.

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