Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Molecular bilayer structure
Patent
1979-01-26
1982-06-15
Nucker, Christine M.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Molecular bilayer structure
23230B, 424 9, 424 12, 424 15, G01N 3356
Patent
active
043350941
DESCRIPTION:
BRIEF SUMMARY
This invention relates to magnetic polyer particles and the process for their production and utilization.
More particularly, the invention relates to magnetic polymer particles as carriers of biologically, preferably pharmaceutically, active substances, the utilization of the magnetic polymer particles, the method of retaining a biologically active substance, preferably a pharmaceutically active substance within a restricted area, and the method of treating diseased tissue with the use of the magnetic polymer particles.
Magnetic polymer particles as carriers of biologically active substances, preferably pharmaceutically active substances, should be useful within many technical and medicinal fields because they can be concentrated by the application of a magnetic field.
The present invention provides magnetic polymer particles as carriers of biologically, preferably pharmaceutically active substance, said particles being particles of a preferably porous polymer in the pores or lattice of which magnetic material is deposited, and the biologically active substance being associated with the polymer.
Further, the invention comprises a method of producing magnetic polymer particles as carriers of biologically, preferably pharmaceutically active substance, in which method particles of a preferably porous polymer, which may carry the biologically active substance, and/or polymerizable monomers are contacted with a colloidal solution of a magnetic material and, optionally, non-associated biologically active substance, the optionally present monomers are polymerized, the solvent is optionally removed, the magnetic material and the optionally present, non-associated biologically active substance being deposited in the pores or lattice of the polymer particles, and the resulting magnetic polymer particles are then associated with the pharmaceutically active substance unless said substance is already associated with the polymer particles.
The invention also comprises the utilization of the magnetic polymer particles as carriers of biologically, preferably pharmaceutically active substance, the substance being associated with particles of a preferably porous polymer and magnetical properties being imparted to said particles by treatment with a magnetic material in the form of particles or colloidal solution.
The invention in addition provides a method of retaining a biologically, preferably pharmaceutically active substance within a restricted area, in which method the substance is associated with a carrier in the form of preferably porous polymer particles to which magnetic properties are imparted by treatment with a magnetic material in the form of particles or a colloidal solution, and the magnetic carrier with the substance associated therewith is then retained within the restricted area by application of a magnetic field.
Finally, the invention provides a method of treating a diseased tissue, in which an effective amount of a pharmaceutically active substance is concentrated in said tissue by the substance being supplied to the tissue associated with a carrier in the form of magnetic, preferably porous polymer particles and concentrated to the diseased tissue by application of a magnetic field.
As polymer use can be made for instance of a polysaccharide, preferably agarose or starch. Another suitable polymer is acrylic polymer. The polymer should be biocompatible. A particular advantage, when used in the treatment of mammals, is gained if the polymer is biodegradable, such as starch which is enzymatically degraded in the organism. Polymers forming too small lattices are unsuitable.
The magnetic material is used in the form of particles of a colloidal solution, preferably colloidal ferrite. Colloidal ferrite is commercially available as ultramicroscopical (about 100 A) ferrite particles surrounded by a thin layer (about 25 A) of a polymer. The particles are prevented by said polymer layer from adhering to each other in a magnetic field. Random collisions (Brownian motion) with the molecules of the carrier liquid ret
REFERENCES:
patent: 3970518 (1976-07-01), Giaever
patent: 3985649 (1976-10-01), Eddelman
patent: 4106488 (1978-08-01), Gordon
patent: 4115534 (1978-12-01), Ithakissios
patent: 4172253 (1979-12-01), Davies et al.
Nye et al., Clinica Chimica Acta, vol. 69, No. 2, Jun. 1976, pp. 387-396.
Ithakissios et al., Clinica Chimica Acta, vol. 84, No. 1/2, Mar. 1978, pp. 69-84.
LandOfFree
Magnetic polymer particles does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Magnetic polymer particles, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Magnetic polymer particles will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1918981