Magnetic nanoparticles and method for producing the same

Details Magnetic nanoparticles and method for producing the same Magnetic nanoparticles and method for producing the same

2005-11-18

2009-06-16

Kiliman, Leszek (Department: 1794)

Stock material or miscellaneous articles

Coated or structually defined flake, particle, cell, strand,...

Particulate matter

C428S404000, C428S405000, C428S406000, C428S407000, C428S690000, C427S212000

Reexamination Certificate

active

07547473

ABSTRACT:
Magnetic nanoparticles and a method for producing the same are disclosed. A carboxylated polysaccharide with various functions such as chelating and ion exchange is covalently bound on the surfaces of magnetic nanoparticles. The polysaccharide-bound magnetic nanoparticles are highly stable, well dispersed, and have many advantages of high adsorption capacity, fast adsorption rate and easy magnetically manipulation. Hence, the polysaccharide-bound magnetic nanoparticles are applied to adsorb many ionic substances, and further act as an adsorbent for wastewater treatment or biochemical separation, a carrier for drugs or gene site-directed delivery, and a magnetic resonance imaging (MRI) contrast agent.

REFERENCES:
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patent: 224025 (2003-04-01), None
Chang et al, “Preparation and adsorption properties of monodisperse chitosan-bound magnetic nanoparticles for removal of Cu(II) ions”. JC&IS, Sep. 9, 2004.
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Yang-Chuang Chang et al., “Monodisperse Chitosan-bound FE3O4Nanoparticles With and Without Adsorbing Gd Ions as MRI Contrast Agents”, pp. 109-111.
Hiroyuki Honda et al., “Development of Chitosan-Conjugated Magnetite for Magnetic Cell Separation” ,Journal of Fermentation and Bioengineering, vol. 86, No. 2, 1998, pp. 191-196.
Yang-Chuang Chang et al., “Adsorption Kinetics and Thermodynamics of Acid Dyes on a Carboxymethylated Chitosan-Conjugated Magnetic Nano-Adsorbent”,Macromolecular Bioscience, Jan. 25, 2005, pp. 254-261.
Yang-Chuang Chang et al., “Conjugation of Monodisperse Chitosan-Bound Magnetic Nanocarrier with Epirubicin for Targeted Cancer Therapy”,Journal of Biomedical Nanotechnology, vol. I, 2005, pp. 1-6.
Yang-Chuang Chang et al., Magnetic Chitosan Nanoparticles: Studies on Chitosan Binding and Adsorption of Co(II) Ions, Reactive and Functional Polymers, Jul. 9, 2005.

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