Magnetic-nanoparticle conjugates and methods of use

Details Magnetic-nanoparticle conjugates and methods of use Magnetic-nanoparticle conjugates and methods of use

2008-08-19

2010-11-09

Jung, Unsu (Department: 1641)

Chemistry: analytical and immunological testing

Involving an insoluble carrier for immobilizing immunochemicals

Carrier is inorganic

C422S051000, C422S068100, C422S105000, C435S006120, C435S007100, C435S007500, C435S969000, C436S518000, C436S525000, C436S528000, C436S529000, C436S548000, C436S069000, C436S073000, C436S149000, C977S773000, C977S918000, C977S920000

Reexamination Certificate

active

07829350

ABSTRACT:
The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked to either non-polymer surface functionalized metal oxides or with functionalized polymers associated with the metal oxides. The novel compositions can be used in assays for detecting target molecules, such as nucleic acids and proteins, in vitro or as magnetic resonance (MR) contrast agents to detect target molecules in living organisms.

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