Drug – bio-affecting and body treating compositions – Inorganic active ingredient containing – Aluminum – calcium or magnesium element – or compound containing
Patent
1995-11-06
1998-07-07
Harrison, Robert H.
Drug, bio-affecting and body treating compositions
Inorganic active ingredient containing
Aluminum, calcium or magnesium element, or compound containing
424451, 424464, 424489, 514870, 514921, 514937, A61K 914, A61K 920, A61K 948
Patent
active
057765049
ABSTRACT:
A magnesium-taurine compound and its method of synthesis. The compound is synthesized by reacting taurine and magnesium in a 2:1 molar ratio. The resulting mixture is diluted with methanol and the remaining clear filtrate is crystallized from methanol. This compound may be administered orally as a nutritional supplement or may be administered orally or intravenously for the therapeutic or prophylactic treatment of pre-eclampsia/eclampsia and acute cardiac conditions.
REFERENCES:
patent: 3725553 (1973-04-01), Giotti et al.
patent: 5514382 (1996-05-01), Sultenfuss
patent: 5582839 (1996-12-01), McCarty
T.W. Anderson et al. (1975) Ischemic heart disease, water hardness and myocardial magnesium. CMA Journal 113:199-203.
S.E. Atahanov, et al. (1992) Modulation of receptor-dependent increase of calcium ions in human platelets by taurine, Arzeim.-Forsch./Drug Res. 42(II):1311-1313.
J. Azuma, et al. (1983) Double-blind randomized crossover trial of taurine in congestive heart failure. Current Therapeutic Res. 34(4):543-557.
S. Bewley, et al. (1991) Doppler investigation of uteroplacental blood flow resistance in the second trimester: a screening study for pre-eclampsia and intrauterine growth retardation. British Journal of Obstetrics and Gynaecology 98:872-879.
T. Dyckner, et al. (1983) Effect of magnesium on blood pressure. British Medical Journal 286:1847-1849.
The Eclampsia Trial Collaborative Group (1995) Which anticonvulsant for women with eclampsia? Evidence from the Collaborative Eclampsia Trial. The Lancet 345:1455-1463.
K.C. Hayes, et al. (1989) Taurine modulates platelet aggregation in cats and human. Am. J. Clin. Nutr. 49:1211-1216.
R.J. Huxtable (1992) Physiological actions of taurine. Physiological Reviews 72(1):101-163.
L.T. Iseri (1984) Magnesium in coronary artery disease. Drugs 28(Suppl. 1):151-160.
M. Malcangio, et al. (1989) Effect of ICV taurine on the impairment of learning, convulsions and death caused by hypoxia. Psychopharmacology 98:316-320.
The Merck Manual (1992) Diagnosis and therapy. Sixteenth Edition, Ch. 179:1870-1871.
T. Motoyama, et al. (1989) Oral magnesium supplementation in patients with essential hypertension. Hypertension 13:227-232.
H.W. Puffer, et al. (1982) Vasoactive effect of sera from preeclamptic patients. Am. J. Obstet. Gynecol. 142:468.
G.M. Rodgers, et al. (1988) Preeclampsia is associated with a serum factor cytotoxic to human endothelial cells. Am. J. Obstet. Gynecol. 159:908-914.
M.P. Ryan, et al. (1984) The role of magnesium in the prevention and control of hypertension. Ann. Clin. Res. 16:82-88.
S.W. Schaffer, et al. (1990) regulation of calcium homeostasis by taurine: role of calmodulin. Taurine: Functional Neurochemistry, Physiology, and Cardiology 217-225.
S.W. Schaffer, et al. (1994) Mechanisms underlying physiological, and pharmacological actions of taurine on myocardial calcium transport. Taurine in Health and Disease 171-180.
A. Schurr, et al. (1987) Taurine improves the recovery of neuronal function following cerebral hypoxia: an in vitro study. Life Sciences 40:2059-2066.
M.S. Seelig, et al. (1974) Magnesium interrelationships in ischemic heart diesase: a review. The American Journal of Clinical Nutrition 27: 59-79.
M. Shechter, et al. (1992) The rationale of magnesium supplementation in acute myocardial infarction. Arch Intern. Med. 152:2189-2196.
G.M. Zaret (1983) Possible treatment of pre-eclampsia with calcium channel blocking agents. Medical Hypotheses 12:303-319.
Harrison Robert H.
Nutrition 21
LandOfFree
Magnesium taurate for prevention and treatment of pre-eclampsia/ does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Magnesium taurate for prevention and treatment of pre-eclampsia/, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Magnesium taurate for prevention and treatment of pre-eclampsia/ will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1202826