Magnesium salt of S-omeprazole

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C546S273700

Reexamination Certificate

active

06894066

ABSTRACT:
A process of producing the magnesium salt of an enantiomer of omeprazole, said process comprising the steps of:i) reacting magnesium with a lower alcohol to produce magnesium alkoxide in solution in the lower alcohol as solvent,ii) adding the neutral form of the enantiomer of omeprazole to the solution, andiii) flash-evaporating the solvent.

REFERENCES:
patent: 5714504 (1998-02-01), Lindberg et al.
patent: 6048981 (2000-04-01), Macel
patent: 6713495 (2004-03-01), Sherman
patent: 0187831 (2001-11-01), None
Chemical & Engineering News, Feb. 2003, pps 32-35.*
US Pharmacopia, 1995, pp. 1843-1844.*
Halbein et al., J. of Pharm. Sci., 58 (1969) pp 911-928.*
Concise Enclyclopedia Chemistry, pp. 872-873 (1993).

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