Magnesium fluoromalonates

Details Magnesium fluoromalonates Magnesium fluoromalonates

1990-02-16

1992-03-31

Dees, Jose G.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

556429, 556437, 562596, 568397, 568419, C07C 6938

Patent

active

051010682

ABSTRACT:
The preparation of magnesium benzyl fluoromalonate and other equivalent materials, the synthetic equivalents of the --CH.sub.2 F moiety, is described. Reaction between these reagents and the in situ-formed imidazolides of various carboxylic acids gives beta-keto-alpha-fluoroesters, which upon hydrogenation and spontaneous decarboxylation yields fluoromethyl ketones in excellent yields. The overall transformation from RCOOH to RCOCH.sub.2 F is thus illustrated.

REFERENCES:
patent: 4518528 (1985-05-01), Rasnick
Rozen, S. et al., Tetrahedron Let. 41:1111-1153, (1985).
Brooks, D. W. et al., Angew. Chem. Int. Ed. Eng. 18:72-74, (1979).
Mansour, T. S. Synth. Commun. 19(3&4):659-665, ((1989).

Affiliated with

Also associated with

Rating

Magnesium fluoromalonates does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Magnesium fluoromalonates, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Magnesium fluoromalonates will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-2261045